Find Research outputs

2025

Impact of water stress to plant epigenetic mechanisms in stress and adaptation

Aanniz, T., El Baaboua, A., Aboulaghras, S., Bouyahya, A., Benali, T., Balahbib, A., El Omari, N., Butnariu, M., Muzammil, K., Yadav, K. K., Al Abdulmonem, W., Lee, L. H., Zengin, G. & Chamkhi, I., 1 Jan 2025, In: Physiologia Plantarum. 177, 1, e70058.

Research output: Journal Publication › Review article › peer-review

Potential use of Ecdysone in protecting wheat (Triticum aestivum) germination under cadmium stress

Lamhamdi, M., Gharbi, S., El Arras, M., El Galiou, O., El Moudden, H., Lee, L. H., Bouyahya, A. & Bakrim, A., Jan 2025, In: Biocatalysis and Agricultural Biotechnology. 63, 103479.

Research output: Journal Publication › Article › peer-review

Probiotics in Depression Management: Efficacy, Mechanisms and Future Directions

Lee, L. H., 15 Jan 2025, In: Progress in Microbes and Molecular Biology. 8, 1, a0000459.

Research output: Journal Publication › Review article › peer-review

Open Access

Subphenotypes of Long COVID and the clinical applications of probiotics

Lim, H. X., Khalid, K., Abdullah, A. D. I., Lee, L. H. & Raja Ali, R. A., Feb 2025, In: Biomedicine and Pharmacotherapy. 183, 117855.

Research output: Journal Publication › Review article › peer-review

Open Access

2024

A Current Overview of Next-Generation Probiotics and Their Prospects in Health and Disease Management

Loo, K. Y., Thong, J. Y. H., Tan, L. T. H., Letchumanan, V., Chan, K. G., Lee, L. H. & Law, J. W. F., 2024, In: Progress in Microbes and Molecular Biology. 7, 1, a0000457.

Research output: Journal Publication › Review article › peer-review

Open Access

1 Citation (Scopus)

A Hitchhiker’s guide to RNA–RNA structure and interaction prediction tools

Tieng, F. Y. F., Abdullah-Zawawi, M. R., Md Shahri, N. A. A., Mohamed-Hussein, Z. A., Lee, L. H. & Ab Mutalib, N. S., 1 Jan 2024, In: Briefings in Bioinformatics. 25, 1, bbad421.

Research output: Journal Publication › Review article › peer-review

Open Access

8 Citations (Scopus)

A pilot study examining periodontally healthy middle-aged humans and monkeys display different levels of alveolar bone resorption, gingival inflammatory infiltrate, and salivary microbiota profile

Lin, B., Pathak, J. L., Gao, H., Zhou, Z., Ser, H. L., Wu, L., Lee, L. H., Wang, L., Chen, J. & Zhong, M., Oct 2024, In: PLoS ONE. 19, 10 October, e0311282.

Research output: Journal Publication › Article › peer-review

Open Access

A Review of Recent Progresses on Olive Oil Chemical Profiling, Extraction Technology, Shelf-life, and Quality Control

Gagour, J., Hallouch, O., Asbbane, A., Bijla, L., Laknifli, A., Lee, L. H., Zengin, G., Bouyahya, A., Sakar, E. H. & Gharby, S., Apr 2024, In: Chemistry and Biodiversity. 21, 4, e202301697.

Research output: Journal Publication › Review article › peer-review

9 Citations (Scopus)

Assessment of anti-hyperglycemic and anti-hyperlipidemic effects of thiazolidine-2,4-dione derivatives in HFD-STZ diabetic animal model

Fettach, S., Thari, F. Z., Karrouchi, K., Benbacer, L., Lee, L. H., Bouyahya, A., Cherrah, Y., Sefrioui, H., Bougrin, K. & Faouzy, M. E. A., 1 Mar 2024, In: Chemico-Biological Interactions. 391, 110902.

Research output: Journal Publication › Article › peer-review

3 Citations (Scopus)

Chemical composition and bioactivity of essential oils from Cistus ladanifer L., Pistacia lentiscus L., and Matricaria chamomilla L

Benali, T., Laghmari, M., Touhtouh, J., Aanniz, T., Lemhadri, A., Daoudi, M. D., Bouyahya, A., Lee, L. H., Ullah, R., Alotaibi, A., Akhazzane, M., Zengin, G. & Hammani, K., Oct 2024, In: Biochemical Systematics and Ecology. 116, 104880.

Research output: Journal Publication › Article › peer-review

1 Citation (Scopus)

Complete Whole-Genome Sequence of Streptomyces sp. MUM 178J, a Potential Anti-Vibrio Agent

Loo, K. Y., Tan, L. T. H., Chua, K. O., Pusparajah, P., Chan, K. G., Lee, L. H., Law, J. W. F. & Letchumanan, V., 7 Feb 2024, In: Progress in Microbes and Molecular Biology. 7, 1, a0000399.

Research output: Journal Publication › Article › peer-review

Open Access

4 Citations (Scopus)

Decoding the Methylation Patterns of ABC Transporters in Colorectal Cancer

Norhisan, N. N., Baharudin, R., Bakarurraini, N. Q. R., Shahri, N. A. A. M., Tieng, F. Y. F., Ismail, I., Abdullah-Zawawi, M. R., Lee, L. H. & Mutalib, N. S. A., 7 Feb 2024, In: Progress in Microbes and Molecular Biology. 7, 1, a0000450.

Research output: Journal Publication › Article › peer-review

Open Access

2 Citations (Scopus)

Effect of storage conditions on physico-chemical characteristics and antioxidants activity of sweet and bitter almond nuts and seeds of aknoul

El Bernoussi, S., Boujemaa, I., El Guezzane, C., Lakhlifi El Idrissi, Z., Santanatoglia, A., Caprioli, G., Bouyahya, A., Ullah, R., Iqbal, Z., Lee, L. H., Harhar, H. & Tabyaoui, M., Aug 2024, In: Food Bioscience. 60, 104488.

Research output: Journal Publication › Article › peer-review

2 Citations (Scopus)

Effects of Mediterranean diets and nutrigenomics on cardiovascular health

Bakrim, S., Aboulaghras, S., Aanniz, T., Benali, T., El Omari, N., El-Shazly, M., Lee, L. H., Mustafa, S. K., Sahib, N., Rebezov, M., Ali Shariati, M., Lorenzo, J. M. & Bouyahya, A., 2024, In: Critical Reviews in Food Science and Nutrition. 64, 21, p. 7589-7608 20 p.

Research output: Journal Publication › Review article › peer-review

4 Citations (Scopus)

Exploring the chemistry, biological effects, and mechanism insights of natural coumaroyltyramine: First report

Bakrim, S., Elouafy, Y., Touhtouh, J., Aanniz, T., El Kadri, K., Khalid, A., Fawzy, S., Mesaik, M. A., Lee, L. H., Chamkhi, I. & Bouyahya, A., Oct 2024, In: Fitoterapia. 178, 106182.

Research output: Journal Publication › Review article › peer-review

1 Citation (Scopus)

Fungal infections of legume crops: Challenges and management approaches

Sbai, H., Hajib, A., Msairi, S., Amalich, S., Bouyahya, A., Lee, L. H., Goh, K. W., Tabyaoui, M. & Harhar, H., Dec 2024, In: Journal of Agriculture and Food Research. 18, 101447.

Research output: Journal Publication › Review article › peer-review

Open Access

Natural Sources, Bioactivities, and Health Benefits of Cianidanol: First Update

Belmehdi, O., Sahib, N., Benali, T., Fernández-Galleguillos, C., Lee, L. H., Benkhaira, N., El Omari, N., Zengin, G. & Bouyahya, A., 2024, In: Food Reviews International. 40, 5, p. 1413-1425 13 p.

Research output: Journal Publication › Review article › peer-review

5 Citations (Scopus)

Natural sources and pharmacological properties of santalenes and santalols

El Hachlafi, N., Benkhaira, N., Mssillou, I., Touhtouh, J., Aanniz, T., Chamkhi, I., El Omari, N., Khalid, A., Abdalla, A. N., Aboulagras, S., El Kadri, K., Abdallah, A. A., Lee, L. H., Bakrim, S. & Bouyahya, A., Aug 2024, In: Industrial Crops and Products. 214, 118567.

Research output: Journal Publication › Review article › peer-review

2 Citations (Scopus)

Nutritional profile, LC-PDA/ESI-MS analysis, antioxidant, and anti-enzymatic activities of hydromethanolic extracts of three Ficus carica varieties from Moroccan Pre-Rif-Taza

Benali, T., Abdnim, R., Khabbach, A., El Hachlafi, N., Kachmar, M. R., Bouyahya, A., Bnouham, M., Gharby, S., Lakhdar, F., Bouymajane, A., Vinci, R. L., Cacciola, F., Lee, L. H., Louahlia, S. & Hammani, K., Aug 2024, In: Food Bioscience. 60, 104493.

Research output: Journal Publication › Article › peer-review

Optimization of torrefaction conditions on antioxidant activity of prickly pear seeds extract using response surface methodology and chemometric analysis

El Guezzane, C., El Moudden, H., Harhar, H., Zarrouk, A., Lee, L. H., Al Abdulmonem, W., Bouyahya, A., Maggi, F., Caprioli, G. & Tabyaoui, M., Dec 2024, In: Journal of Agriculture and Food Research. 18, 101465.

Research output: Journal Publication › Article › peer-review

Open Access

1 Citation (Scopus)

Optimization of ultrasound-assisted extraction of phenols from Crocus sativus by-products using sunflower oil as a sustainable solvent alternative

Slimani, C., Rais, C., Mansouri, F., Rais, S., Benjelloun, M., Ullah, R., Iqbal, Z., Goh, K. W., Lee, L. H., Bouyahya, A. & Lazraq, A., 30 Oct 2024, In: Food Chemistry: X. 23, 101579.

Research output: Journal Publication › Article › peer-review

Open Access

4 Citations (Scopus)

Protective and stochastic correlation between infectious diseases and autoimmune disorders

Aboulaghras, S., Bouyahya, A., El Kadri, K., Khalid, A., Abdalla, A. N., Hassani, R., Lee, L. H. & Bakrim, S., Nov 2024, In: Microbial Pathogenesis. 196, 106919.

Research output: Journal Publication › Review article › peer-review

Role of SarA in Staphylococcus aureus: A Virulence Target For Therapeutic Strategies

Kuai, Y. H., Law, J. W. F., Ong, Y. S., Letchumanan, V., Lee, L. H. & Tan, L. T. H., 7 Feb 2024, In: Progress in Microbes and Molecular Biology. 7, 1, a0000444.

Research output: Journal Publication › Review article › peer-review

Open Access

3 Citations (Scopus)

Streptomyces sp. MUM 195J: A Promising Probiotic for Controlling Vibrio parahaemolyticus Infection in Aquaculture

Goh, J. X. H., Tan, L. T. H., Law, J. W. F., Kuppusamy, G., Janaranjani, M., Khaw, K. Y., Yap, W. H., Chan, K. G., Letchumanan, V., Lee, L. H. & Goh, B. H., 7 Feb 2024, In: Progress in Microbes and Molecular Biology. 7, 1, a0000443.

Research output: Journal Publication › Article › peer-review

Open Access

3 Citations (Scopus)

The Impact of Antidepressants on Gut Microbiome and Depression Management

Tang, E. K., Loo, K. Y., Thye, A. Y. K., Fei, J. L. W., Tan, L. T. H., Selvaraja, M., Thurairajasingam, S., Lee, L. H. & Letchumanan, V., 7 Feb 2024, In: Progress in Microbes and Molecular Biology. 7, 1, a0000446.

Research output: Journal Publication › Review article › peer-review

Open Access

3 Citations (Scopus)

The impact of geographical location on the nutritional quality, chemical composition, and antioxidant activity of Cucurbita maxima (rouge vif d'Etampes) seed oil

Boujemaa, I., El Bernoussi, S., Lakhlifi El Idrissi, Z., El Idrissi, Y., El Guezzane, C., Lee, L. H., Ullah, R., Bari, A., Bouyahya, A., Harhar, H. & Tabyaoui, M., Aug 2024, In: Biochemical Systematics and Ecology. 115, 104835.

Research output: Journal Publication › Article › peer-review

2 Citations (Scopus)

Thermal oxidative stability and kinetics of lipophilic bioactive compounds degradation during accelerated storage of unroasted and roasted peanut oil

LakhlifiEl Idrissi, Z., Amakhmakh, M., El Moudden, H., El Guezzane, C., Ullah, R., Bari, A., Bouyahya, A., Lee, L. H., Harhar, H. & Tabyaoui, M., Jul 2024, In: Journal of Food Composition and Analysis. 131, 106239.

Research output: Journal Publication › Article › peer-review

6 Citations (Scopus)

What hidden treasure resides beneath the waves? Phytochemistry, pharmacological properties and uses of Halopteris scoparia (Linnaeus) Sauvageau 1904: An overview

Aalilou, Y., Moussa, H., Lee, L. H., Bouyahya, A., Zengin, G. & Faouzi, M. E. A., Jul 2024, In: Fitoterapia. 176, 106016.

Research output: Journal Publication › Review article › peer-review

2023

A Keystone Gut Bacterium Christensenella minuta—A Potential Biotherapeutic Agent for Obesity and Associated Metabolic Diseases

Ang, W. S., Law, J. W. F., Letchumanan, V., Hong, K. W., Wong, S. H., Ab Mutalib, N. S., Chan, K. G., Lee, L. H. & Tan, L. T. H., Jul 2023, In: Foods. 12, 13, 2485.

Research output: Journal Publication › Review article › peer-review

Open Access

25 Citations (Scopus)

A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression

Johnson, D., Letchumanan, V., Thum, C. C., Thurairajasingam, S. & Lee, L. H., Mar 2023, In: Nutrients. 15, 6, 1382.

Research output: Journal Publication › Review article › peer-review

Open Access

28 Citations (Scopus)

Anticancer clinical efficiency and stochastic mechanisms of belinostat

El Omari, N., Bakrim, S., Khalid, A., Albratty, M., Abdalla, A. N., Lee, L. H., Goh, K. W., Ming, L. C. & Bouyahya, A., Sept 2023, In: Biomedicine and Pharmacotherapy. 165, 115212.

Research output: Journal Publication › Review article › peer-review

Open Access

15 Citations (Scopus)

Antimicrobial, antioxidant, α-amylase and α-glucosidase inhibitory activities of a chemically characterized essential oil from Lavandula angustifolia Mill., in vitro and in silico investigations

Jeddi, M., El Hachlafi, N., El Fadili, M., Benkhaira, N., Al-Mijalli, S. H., Kandsi, F., Abdallah, E. M., Ouaritini, Z. B., Bouyahya, A., Lee, L. H., Zengin, G., Mrabti, H. N. & Fikri-Benbrahim, K., Dec 2023, In: Biochemical Systematics and Ecology. 111, 104731.

Research output: Journal Publication › Article › peer-review

31 Citations (Scopus)

A piericidin-producing Streptomyces strain: identification and antagonistic activity on Xanthomonas oryzae

He, Y. W., Azad, S. M., Cui, Y., Yao, R., Law, W. F. J., Lee, L. H., Hao, X. & Zhang, H., 2023, In: Acta Microbiologica Sinica. 63, 4, p. 1447-1459 13 p.

Research output: Journal Publication › Article › peer-review

2 Citations (Scopus)

Association between Physical Activity, Body Composition, and Metabolic Disorders in Middle-Aged Women of Ksar el Kebir (Morocco)

Harraqui, K., Oudghiri, D. E., Mrabti, H. N., Hannoun, Z., Lee, L. H., Assaggaf, H., Qasem, A., Goh, K. W., Ming, L. C., Tan, C. S., Bouyahya, A. & Bour, A., Feb 2023, In: International Journal of Environmental Research and Public Health. 20, 3, 1739.

Research output: Journal Publication › Article › peer-review

Open Access

4 Citations (Scopus)

Chemical Profiling and Biological Properties of Essential Oils of Lavandula stoechas L. Collected from Three Moroccan Sites: In Vitro and In Silico Investigations

Benali, T., Lemhadri, A., Harboul, K., Chtibi, H., Khabbach, A., Jadouali, S. M., Quesada-Romero, L., Louahlia, S., Hammani, K., Ghaleb, A., Lee, L. H., Bouyahya, A., Rusu, M. E. & Akhazzane, M., Mar 2023, In: Plants. 12, 6, 1413.

Research output: Journal Publication › Article › peer-review

Open Access

19 Citations (Scopus)

Combination of sweet orange, lentisk and lemon eucalyptus essential oils: Optimization of a new complete antimicrobial formulation using a mixture design methodology

Al-Mijalli, S. H., Jeddi, M., El Hachlafi, N., M. Abdallah, E., Assaggaf, H., Qasem, A., S. Rajab, B., Lee, L. H., Bouyahya, A., Goh, K. W., Ming, L. C. & Mrabti, H. N., Sept 2023, In: Heliyon. 9, 9, e19814.

Research output: Journal Publication › Article › peer-review

Open Access

5 Citations (Scopus)

Complete Whole Genome Sequence of Vibrio parahaemolyticus RP0132 Strain Isolated from Shrimp in Malaysia

Loo, K. Y., Tan, L. T. H., Law, J. W. F., Chua, K. O., Pusparajah, P., Lee, L. H. & Letchumanan, V., 4 Jan 2023, In: Progress in Microbes and Molecular Biology. 6, 1, a0000388.

Research output: Journal Publication › Article › peer-review

Open Access

3 Citations (Scopus)

Comprehensive Analysis of microRNA Methylation Profiles and Determination of Their Functional Significance in Colorectal Cancer: A Study Protocol

Ab Mutalib, N. S., Ismail, I., Zawawi, M. R. A., Abu, N., Sulaiman, S. A., Tan, L. T. H. & Lee, L. H., 4 Jan 2023, In: Progress in Microbes and Molecular Biology. 6, 1, a0000389.

Research output: Journal Publication › Article › peer-review

Open Access

6 Citations (Scopus)

Detection of multidrug resistant Vibrio parahaemolyticus and anti-Vibrio Streptomyces sp. MUM 178J

Loo, K. Y., Tan, L. T. H., Law, J. W. F., Pusparajah, P., Lee, L. H. & Letchumanan, V., 4 Jan 2023, In: Progress in Microbes and Molecular Biology. 6, 1, a0000347.

Research output: Journal Publication › Article › peer-review

Open Access

9 Citations (Scopus)

Editorial: Evidence-based on health benefits: probiotics, micronutrients, and edible plants

Lee, L. H., Goh, B. H., Dilokthornsakul, P. & Saokaew, S., 2023, In: Frontiers in Nutrition. 10, 1272456.

Research output: Journal Publication › Editorial

Open Access

Editorial: Aquatic microorganism and their response to environment virulence and antimicrobial resistance

Deng, Y., Fu, S., Lee, L. H., Feng, J. & Huang, J., 2023, In: Frontiers in Marine Science. 10, 1230258.

Research output: Journal Publication › Editorial

Open Access

1 Citation (Scopus)

Editorial: Roles of microbes in esophageal disease

Lee, L. H., Gao, X. & Sun, G., 2023, In: Frontiers in Cellular and Infection Microbiology. 13, 1339579.

Research output: Journal Publication › Editorial

Open Access

Exploring the antibacterial mechanisms of chemically characterized essential oils from leaves and buds of Syzygium aromaticum (L.) Merr. et Perry against Staphylococcus aureus and Pseudomonas aeruginosa

Al-Mijalli, S. H., El Hachlafi, N., Abdallah, E. M., Jeddi, M., Assaggaf, H., Qasem, A., Alnasser, S. M., Attar, A., Naem, M. A., Lee, L. H., Bouyahya, A. & Mrabti, H. N., 1 Dec 2023, In: Industrial Crops and Products. 205, 117561.

Research output: Journal Publication › Article › peer-review

11 Citations (Scopus)

Fructose promotes pyoluteorin biosynthesis via the CbrAB-CrcZ-Hfq/Crc pathway in the biocontrol strain Pseudomonas PA1201

Cui, Y., Song, K., Jin, Z. J., Lee, L. H., Thawai, C. & He, Y. W., Dec 2023, In: Synthetic and Systems Biotechnology. 8, 4, p. 618-628 11 p.

Research output: Journal Publication › Article › peer-review

Open Access

2 Citations (Scopus)

HPLC-DAD-ESI/MS phytochemical investigation, antioxidant, and antidiabetic activities of Moroccan Rosa canina L. extracts

Mourabit, Y., El Hajjaji, S., Taha, D., Badaoui, B., El Yadini, M., Rusu, M. E., Lee, L. H., Bouyahya, A. & Bourais, I., Sept 2023, In: Biocatalysis and Agricultural Biotechnology. 52, 102817.

Research output: Journal Publication › Article › peer-review

Open Access

9 Citations (Scopus)

Investigating DNA Methylation of Solute Carrier Genes in Colorectal Cancer: A Comprehensive Analysis Using Microarray and Bioinformatics Tools

Zabidi, N. A. N., Baharudin, R., Bakarurraini, N. Q. R., Shahri, N. A. A. M., Fu, F. T. Y., Ismail, I., Zawawi, M. R. A., Law, J. W. F., Lee, L. H. & Mutalib, N. S. A., 4 Jan 2023, In: Progress in Microbes and Molecular Biology. 6, 1, a0000393.

Research output: Journal Publication › Article › peer-review

Open Access

3 Citations (Scopus)

Investigation of roasting and photo-oxidative stability of cold-pressed peanut oil: Lipid composition, quality characteristics, and antioxidant capacity

El Idrissi, Z. L., Elouafy, Y., El Moudden, H., El Guezzane, C., Lorenzo, J. M., Lee, L. H., Bouyahya, A., Maggi, F., Caprioli, G., Harhar, H. & Tabyaoui, M., Oct 2023, In: Food Bioscience. 55, 103046.

Research output: Journal Publication › Article › peer-review

17 Citations (Scopus)

Molecular mechanisms underlying the clinical efficacy of panobinostat involve Stochasticity of epigenetic signaling, sensitization to anticancer drugs, and induction of cellular cell death related to cellular stresses

El Omari, N., Bakrim, S., Khalid, A., Abdalla, A. N., Almalki, W. H., Lee, L. H., Ardianto, C., Ming, L. C. & Bouyahya, A., Aug 2023, In: Biomedicine and Pharmacotherapy. 164, 114886.

Research output: Journal Publication › Article › peer-review

Open Access

10 Citations (Scopus)

Molecular mechanistic pathways underlying the anticancer therapeutic efficiency of romidepsin

El Omari, N., Lee, L. H., Bakrim, S., Makeen, H. A., Alhazmi, H. A., Mohan, S., Khalid, A., Ming, L. C. & Bouyahya, A., Aug 2023, In: Biomedicine and Pharmacotherapy. 164, 114774.

Research output: Journal Publication › Review article › peer-review

Open Access

15 Citations (Scopus)

Phytochemical analysis and evaluation of antimicrobial, antioxidant, and antidiabetic activities of essential oils from Moroccan medicinal plants: Mentha suaveolens, Lavandula stoechas, and Ammi visnaga

El Hachlafi, N., Benkhaira, N., Al-Mijalli, S. H., Mrabti, H. N., Abdnim, R., Abdallah, E. M., Jeddi, M., Bnouham, M., Lee, L. H., Ardianto, C., Ming, L. C., Bouyahya, A. & Fikri-Benbrahim, K., Aug 2023, In: Biomedicine and Pharmacotherapy. 164, 114937.

Research output: Journal Publication › Article › peer-review

Open Access

59 Citations (Scopus)

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