TY - JOUR
T1 - Investigating DNA Methylation of Solute Carrier Genes in Colorectal Cancer
T2 - A Comprehensive Analysis Using Microarray and Bioinformatics Tools
AU - Zabidi, Nur Alia Natasya
AU - Baharudin, Rashidah
AU - Bakarurraini, Nurul Qistina Rus
AU - Shahri, Nur Alyaa Afifah Md
AU - Fu, Francis Tieng Yew
AU - Ismail, Imilia
AU - Zawawi, Muhammad Redha Abdullah
AU - Law, Jodi Woan Fei
AU - Lee, Learn Han
AU - Mutalib, Nurul Syakima Ab
N1 - Publisher Copyright:
© 2023, HH Publisher. All rights reserved.
PY - 2023/1/4
Y1 - 2023/1/4
N2 - Background: Colorectal cancer (CRC) is a major global health concern, with a significant impact on morbidity and mortality. The molecular mechanisms underlying CRC, especially DNA methylation patterns in solute carrier (SLC) genes, have gained attention due to their potential role in CRC initiation and progression. SLC genes encode transporters that play vital roles in maintaining cellular homeostasis, and alterations in their DNA methylation can influence nutrient and metabolite transport, impacting cancer cell behavior. This proposal aims to investigate the DNA methylation status of SLC genes in CRC, utilizing microarray technology and a suite of bioinformatics tools. Methods: Microarray methylation data from CRC and adjacent normal tissues underwent preprocessing, differential methylation analysis, functional enrichment exploration, and correlation analysis for a detailed study of methylation patterns. Results: This study decoded the epigenetic landscape of SLC genes in CRC, promising innovative therapeutic strategies and improved patient outcomes to combat this prevalent malignancy.
AB - Background: Colorectal cancer (CRC) is a major global health concern, with a significant impact on morbidity and mortality. The molecular mechanisms underlying CRC, especially DNA methylation patterns in solute carrier (SLC) genes, have gained attention due to their potential role in CRC initiation and progression. SLC genes encode transporters that play vital roles in maintaining cellular homeostasis, and alterations in their DNA methylation can influence nutrient and metabolite transport, impacting cancer cell behavior. This proposal aims to investigate the DNA methylation status of SLC genes in CRC, utilizing microarray technology and a suite of bioinformatics tools. Methods: Microarray methylation data from CRC and adjacent normal tissues underwent preprocessing, differential methylation analysis, functional enrichment exploration, and correlation analysis for a detailed study of methylation patterns. Results: This study decoded the epigenetic landscape of SLC genes in CRC, promising innovative therapeutic strategies and improved patient outcomes to combat this prevalent malignancy.
KW - Biomarker
KW - Colorectal cancer
KW - DNA methylation
KW - Precision medicine
KW - SDG 3 Good health and well-being
KW - Solute carrier genes
UR - http://www.scopus.com/inward/record.url?scp=85180882578&partnerID=8YFLogxK
U2 - 10.36877/pmmb.a0000393
DO - 10.36877/pmmb.a0000393
M3 - Article
AN - SCOPUS:85180882578
SN - 2637-1049
VL - 6
JO - Progress in Microbes and Molecular Biology
JF - Progress in Microbes and Molecular Biology
IS - 1
M1 - a0000393
ER -
