The Role of Human Gut Microbe Ruminococcus gnavus in Inflammatory Diseases

Sasmitra Kandasamy, Vengadesh Letchumanan, Kar Wai Hong, Kah Ooi Chua, Nurul Syakima Ab Mutalib, Alvin Lai Oon Ng, Long Chiau Ming, Hui Xuan Lim, Sivakumar Thurairajasingam, Jodi Woan Fei Law, Loh Teng Hern Tan

Research output: Journal PublicationReview articlepeer-review

2 Citations (Scopus)


Dysbiosis is a prominent factor in numerous inflammatory conditions, with Ruminococcus gnavus, a prevalent gut microbe, implicated in inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), eczema, metabolic disorders, and rheumatic diseases. R. gnavus contributes to inflammation by producing an inflammatory polysaccharide and degrading mucin. The increasing evidence of elevated R. gnavus abundance in various inflammatory conditions suggests its potential as a therapeutic target. Despite this, there are limited studies on treatment strategies targeting R. gnavus. This article provides a comprehensive overview of the association between R. gnavus and diverse inflammatory conditions, highlighting the need for further research to explore effective treatment options against this bacterium.

Original languageEnglish
Article numbera0000396
JournalProgress in Microbes and Molecular Biology
Issue number1
Publication statusPublished - 4 Jan 2023
Externally publishedYes


  • Ruminococcus gnavus
  • SDG 3 Good health and well-being
  • gut microbiome
  • inflammatory diseases
  • probiotics

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Microbiology (medical)


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