The Role of Human Gut Microbe Ruminococcus gnavus in Inflammatory Diseases

Sasmitra Kandasamy; Vengadesh Letchumanan; Kar Wai Hong; Kah Ooi Chua; Nurul Syakima Ab Mutalib; Alvin Lai Oon Ng; Long Chiau Ming; Hui Xuan Lim; Sivakumar Thurairajasingam; Jodi Woan Fei Law; Loh Teng Hern Tan

doi:10.36877/pmmb.a0000396

The Role of Human Gut Microbe Ruminococcus gnavus in Inflammatory Diseases

Sasmitra Kandasamy, Vengadesh Letchumanan, Kar Wai Hong, Kah Ooi Chua, Nurul Syakima Ab Mutalib, Alvin Lai Oon Ng, Long Chiau Ming, Hui Xuan Lim, Sivakumar Thurairajasingam, Jodi Woan Fei Law, Loh Teng Hern Tan

Research output: Journal Publication › Review article › peer-review

5 Citations (Scopus)

Abstract

Dysbiosis is a prominent factor in numerous inflammatory conditions, with Ruminococcus gnavus, a prevalent gut microbe, implicated in inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), eczema, metabolic disorders, and rheumatic diseases. R. gnavus contributes to inflammation by producing an inflammatory polysaccharide and degrading mucin. The increasing evidence of elevated R. gnavus abundance in various inflammatory conditions suggests its potential as a therapeutic target. Despite this, there are limited studies on treatment strategies targeting R. gnavus. This article provides a comprehensive overview of the association between R. gnavus and diverse inflammatory conditions, highlighting the need for further research to explore effective treatment options against this bacterium.

Original language	English
Article number	a0000396
Journal	Progress in Microbes and Molecular Biology
Volume	6
Issue number	1
DOIs	https://doi.org/10.36877/pmmb.a0000396
Publication status	Published - 4 Jan 2023
Externally published	Yes

Keywords

Ruminococcus gnavus
SDG 3 Good health and well-being
gut microbiome
inflammatory diseases
probiotics

ASJC Scopus subject areas

Microbiology
Molecular Biology
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Microbiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.36877/pmmb.a0000396

Cite this

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title = "The Role of Human Gut Microbe Ruminococcus gnavus in Inflammatory Diseases",

abstract = "Dysbiosis is a prominent factor in numerous inflammatory conditions, with Ruminococcus gnavus, a prevalent gut microbe, implicated in inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), eczema, metabolic disorders, and rheumatic diseases. R. gnavus contributes to inflammation by producing an inflammatory polysaccharide and degrading mucin. The increasing evidence of elevated R. gnavus abundance in various inflammatory conditions suggests its potential as a therapeutic target. Despite this, there are limited studies on treatment strategies targeting R. gnavus. This article provides a comprehensive overview of the association between R. gnavus and diverse inflammatory conditions, highlighting the need for further research to explore effective treatment options against this bacterium.",

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author = "Sasmitra Kandasamy and Vengadesh Letchumanan and Hong, {Kar Wai} and Chua, {Kah Ooi} and Mutalib, {Nurul Syakima Ab} and Ng, {Alvin Lai Oon} and Ming, {Long Chiau} and Lim, {Hui Xuan} and Sivakumar Thurairajasingam and Law, {Jodi Woan Fei} and Tan, {Loh Teng Hern}",

year = "2023",

month = jan,

day = "4",

doi = "10.36877/pmmb.a0000396",

language = "English",

volume = "6",

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AU - Kandasamy, Sasmitra

AU - Letchumanan, Vengadesh

AU - Hong, Kar Wai

AU - Chua, Kah Ooi

AU - Mutalib, Nurul Syakima Ab

AU - Ng, Alvin Lai Oon

AU - Ming, Long Chiau

AU - Lim, Hui Xuan

AU - Thurairajasingam, Sivakumar

AU - Law, Jodi Woan Fei

AU - Tan, Loh Teng Hern

PY - 2023/1/4

Y1 - 2023/1/4

N2 - Dysbiosis is a prominent factor in numerous inflammatory conditions, with Ruminococcus gnavus, a prevalent gut microbe, implicated in inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), eczema, metabolic disorders, and rheumatic diseases. R. gnavus contributes to inflammation by producing an inflammatory polysaccharide and degrading mucin. The increasing evidence of elevated R. gnavus abundance in various inflammatory conditions suggests its potential as a therapeutic target. Despite this, there are limited studies on treatment strategies targeting R. gnavus. This article provides a comprehensive overview of the association between R. gnavus and diverse inflammatory conditions, highlighting the need for further research to explore effective treatment options against this bacterium.

AB - Dysbiosis is a prominent factor in numerous inflammatory conditions, with Ruminococcus gnavus, a prevalent gut microbe, implicated in inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), eczema, metabolic disorders, and rheumatic diseases. R. gnavus contributes to inflammation by producing an inflammatory polysaccharide and degrading mucin. The increasing evidence of elevated R. gnavus abundance in various inflammatory conditions suggests its potential as a therapeutic target. Despite this, there are limited studies on treatment strategies targeting R. gnavus. This article provides a comprehensive overview of the association between R. gnavus and diverse inflammatory conditions, highlighting the need for further research to explore effective treatment options against this bacterium.

KW - Ruminococcus gnavus

KW - SDG 3 Good health and well-being

KW - gut microbiome

KW - inflammatory diseases

KW - probiotics

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U2 - 10.36877/pmmb.a0000396

DO - 10.36877/pmmb.a0000396

M3 - Review article

AN - SCOPUS:85181516454

SN - 2637-1049

VL - 6

JO - Progress in Microbes and Molecular Biology

JF - Progress in Microbes and Molecular Biology

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ER -

The Role of Human Gut Microbe Ruminococcus gnavus in Inflammatory Diseases

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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