Find Research outputs

2024

Association of Retinal Biomarkers With the Subtypes of Ischemic Stroke and an Automated Classification Model

Xiong, Z., Kwapong, W. R., Liu, S., Chen, T., Xu, K., Mao, H., Hao, J., Cao, L., Liu, J., Zheng, Y., Wang, H., Yan, Y., Ye, C., Wu, B., Qi, H. & Zhao, Y., Jul 2024, In: Investigative Ophthalmology and Visual Science. 65, 8, 50.

Research output: Journal Publication › Article › peer-review

Open Access

3 Citations (Scopus)

Stereolithographic Rapid Prototyping of Clear, Foldable, Non-Refractive Intraocular Lens Designs: A Proof-of-Concept Study

Hidalgo-Alvarez, V., Falcon, N. D., Eldred, J., Wormstone, M. & Saeed, A., 2024, In: Current Eye Research. 49, 8, p. 843-852 10 p.

Research output: Journal Publication › Article › peer-review

Open Access

1 Citation (Scopus)

2023

Crystalline lens nuclear age prediction as a new biomarker of nucleus degeneration

Guo, M., Higashita, R., Lin, C., Hu, L., Chen, W., Li, F., Lai, G. W. K., Nguyen, A., Sakata, R., Okamoto, K., Tang, B., Xu, Y., Fu, H., Gao, F., Aihara, M., Zhang, X., Yuan, J., Lin, S., Leung, C. K. S. & Liu, J., 26 Jul 2023, In: British Journal of Ophthalmology. 108, 4, p. 513-521 9 p.

Research output: Journal Publication › Article › peer-review

Deep segmentation of OCTA for evaluation and association of changes of retinal microvasculature with Alzheimer’s disease and mild cognitive impairment

Xie, J., Yi, Q., Wu, Y., Zheng, Y., Liu, Y., Macerollo, A., Fu, H., Xu, Y., Zhang, J., Behera, A., Fan, C., Frangi, A. F., Liu, J., Lu, Q., Qi, H. & Zhao, Y., 3 Jan 2023, In: British Journal of Ophthalmology. 108, 3, p. 432-439 8 p.

Research output: Journal Publication › Article › peer-review

Open Access

26 Citations (Scopus)

Reproducibility of deep learning based scleral spur localisation and anterior chamber angle measurements from anterior segment optical coherence tomography images

Liu, P., Higashita, R., Guo, P. Y., Okamoto, K., Li, F., Nguyen, A., Sakata, R., Duan, L., Aihara, M., Lin, S., Zhang, X., Leung, C. K. S. & Liu, J., 2023, In: British Journal of Ophthalmology. 107, 6, p. 802-808 7 p.

Research output: Journal Publication › Article › peer-review

Open Access

19 Citations (Scopus)

Retinal layers changes in patients with age-related macular degeneration treated with intravitreal anti-VEGF agents

Zhou, D., Hu, Y., Qiu, Z., Liu, Z., Jiang, H., Kawasaki, R. & Liu, J., Dec 2023, In: BMC Ophthalmology. 23, 1, 451.

Research output: Journal Publication › Article › peer-review

Open Access

1 Citation (Scopus)

2022

27 Advancing the basic understanding and management of posterior capsule opacification following cataract surgery using human donor eyes

Wormstone, M., 1 Nov 2022, In: BMJ Open Ophthalmology. 7, p. A11-A12

Research output: Journal Publication › Article › peer-review

Open Access

2 Citations (Scopus)

Dynamic analysis of iris changes and a deep learning system for automated angle-closure classification based on AS-OCT videos

Hao, L., Hu, Y., Xu, Y., Fu, H., Miao, H., Zheng, C. & Liu, J., Dec 2022, In: Eye and Vision. 9, 1, 41.

Research output: Journal Publication › Article › peer-review

Open Access

5 Citations (Scopus)

2021

Assessment of intraocular lens/capsular bag biomechanical interactions following cataract surgery in a human in vitro graded culture capsular bag model

Wormstone, I. M., Damm, N. B., Kelp, M. & Eldred, J. A., Apr 2021, In: Experimental Eye Research. 205, 108487.

Research output: Journal Publication › Article › peer-review

20 Citations (Scopus)

Fluorofenidone inhibits the epithelial-mesenchymal transition in human lens epithelial cell line FHL 124: a promising therapeutic strategy against posterior capsular opacification

Wormstone, M., 2021, In: Arquivos Brasileiros de Oftalmologia. 84, 3, p. 303 1 p.

Research output: Journal Publication › Article › peer-review

Open Access

GSH levels serve as a biological redox switch regulating sulforaphane-induced cell fate in human lens cells

Huynh, T. P. N., Bowater, R. P., Bernuzzi, F., Saha, S. & Wormstone, I. M., Dec 2021, In: Investigative Ophthalmology and Visual Science. 62, 15, 2.

Research output: Journal Publication › Article › peer-review

Open Access

14 Citations (Scopus)

Ocular anatomical and functional characteristics in anisometropic chinese children

Zhong, Y., Zeng, L., Chen, Z., Yang, J. & Liu, J., May 2021, In: Optometry and Vision Science. 98, 5, p. 476-482 7 p.

Research output: Journal Publication › Article › peer-review

4 Citations (Scopus)

Posterior capsule opacification: What's in the bag?

Wormstone, I. M., Wormstone, Y. M., Smith, A. J. O. & Eldred, J. A., May 2021, In: Progress in Retinal and Eye Research. 82, 100905.

Research output: Journal Publication › Review article › peer-review

Open Access

140 Citations (Scopus)

2020

A retrospective comparison of deep learning to manual annotations for optic disc and optic cup segmentation in fundus photographs

iChallenge-GON study group, 2020, In: Translational Vision Science and Technology. 9, 2, p. 1-11 11 p., 33.

Research output: Journal Publication › Article › peer-review

Open Access

18 Citations (Scopus)

Assessment of generative adversarial networks model for synthetic optical coherence tomography images of retinal disorders

Zheng, C., Xie, X., Zhou, K., Chen, B., Chen, J., Ye, H., Li, W., Qiao, T., Gao, S., Yang, J. & Liu, J., 2020, In: Translational Vision Science and Technology. 9, 2, p. 1-9 9 p., 29.

Research output: Journal Publication › Article › peer-review

Open Access

49 Citations (Scopus)

The human capsular bag model of posterior capsule opacification

Wormstone, I. M., 1 Feb 2020, In: Eye. 34, 2, p. 225-231 7 p.

Research output: Journal Publication › Article › peer-review

Open Access

23 Citations (Scopus)

Upside-down position leads to choroidal expansion and anterior chamber shallowing: OCT study

Li, F., Li, H., Yang, J., Liu, J., Aung, T. & Zhang, X., 1 Jun 2020, In: British Journal of Ophthalmology. 104, 6, p. 790-794 5 p.

Research output: Journal Publication › Article › peer-review

9 Citations (Scopus)

2019

A Deep Learning System for Automated Angle-Closure Detection in Anterior Segment Optical Coherence Tomography Images

Fu, H., Baskaran, M., Xu, Y., Lin, S., Wong, D. W. K., Liu, J., Tun, T. A., Mahesh, M., Perera, S. A. & Aung, T., Jul 2019, In: American Journal of Ophthalmology. 203, p. 37-45 9 p.

Research output: Journal Publication › Article › peer-review

Open Access

125 Citations (Scopus)

A genome-wide association study implicates that the TTC39C gene is associated with diabetic maculopathy with decreased visual acuity

Meng, W., Chan, B. W., Ezeonwumelu, C., Hébert, H. L., Campbell, A., Soler, V. & Palmer, C. N. A., 4 May 2019, In: Ophthalmic Genetics. 40, 3, p. 252-258 7 p.

Research output: Journal Publication › Article › peer-review

Open Access

9 Citations (Scopus)

An in vitro human lens capsular bag model adopting a graded culture regime to assess putative impact of iols on pco formation

Eldred, J. A., Zheng, J., Chen, S. & Wormstone, I. M., 1 Jan 2019, In: Investigative Ophthalmology and Visual Science. 60, 1, p. 113-122 10 p.

Research output: Journal Publication › Article › peer-review

Open Access

32 Citations (Scopus)

Development and Validation of a Deep Learning System to Detect Glaucomatous Optic Neuropathy Using Fundus Photographs

Liu, H., Li, L., Wormstone, I. M., Qiao, C., Zhang, C., Liu, P., Li, S., Wang, H., Mou, D., Pang, R., Yang, D., Zangwill, L. M., Moghimi, S., Hou, H., Bowd, C., Jiang, L., Chen, Y., Hu, M., Xu, Y. & Kang, H. & 10 others, Ji, X., Chang, R., Tham, C., Cheung, C., Ting, D. S. W., Wong, T. Y., Wang, Z., Weinreb, R. N., Xu, M. & Wang, N., Dec 2019, In: JAMA Ophthalmology. 137, 12, p. 1353-1360 8 p.

Research output: Journal Publication › Article › peer-review

Open Access

234 Citations (Scopus)

Resveratrol inhibits wound healing and lens fibrosis: A putative candidate for posterior capsule opacification prevention

Smith, A. J. O., Eldred, J. A. & Wormstone, I. M., 1 Sept 2019, In: Investigative Ophthalmology and Visual Science. 60, 12, p. 3863-3877 15 p.

Research output: Journal Publication › Article › peer-review

Open Access

27 Citations (Scopus)

基于深度学习OCT辅助诊断湿性年龄相关性黄斑变性算法的应用

Translated title of the contribution: The application value of deep learning OCT on wet age-related macular degeneration assisted diagnosisGong, Y., Gu, Z., Hu, Y., Liao, Y., Ye, T., Liu, D. & Liu, J., 10 Aug 2019, In: Zhonghua Shiyan Yanke Zazhi/Chinese Journal of Experimental Ophthalmology. 37, 8, p. 658-662 5 p.

Research output: Journal Publication › Article › peer-review

1 Citation (Scopus)

2018

A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes

Wellcome Trust Case Control Consortium 2 (WTCCC2), Surrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools (SUMMIT) study group, Nov 2018, In: Acta Ophthalmologica. 96, 7, p. e811-e819

Research output: Journal Publication › Article › peer-review

Open Access

62 Citations (Scopus)

Mutation profiles of congenital cataract genes in 21 northern chinese families

Zhang, X. H., Da Wang, J., Jia, H. Y., Zhang, J. S., Li, Y., Xiong, Y., Li, J., Li, X. X., Huang, Y., Zhu, G. Y., Rong, S. S., Wormstone, M. & Wan, X. H., 20 Jul 2018, In: Molecular Vision. 24, p. 471-477 7 p.

Research output: Journal Publication › Article › peer-review

26 Citations (Scopus)

基于机器学习的人工智能技术在眼科中的应用进展

Translated title of the contribution: Application progress in ophthalmology using artificial intelligence based on machine learningZhao, Q., Shen, L. L. & Lai, M. Y., 8 Sept 2018, In: International Eye Science. 18, 9, p. 1630-1634 5 p.

Research output: Journal Publication › Article › peer-review

3 Citations (Scopus)

2016

A genome-wide association study provides new evidence that CACNA1C gene is associated with diabetic cataract

Chang, C., Zhang, K., Veluchamy, A., Hébert, H. L., Looker, H. C., Colhoun, H. M., Palmer, C. N. A. & Meng, W., Apr 2016, In: Investigative Ophthalmology and Visual Science. 57, 4, p. 2246-2250 5 p.

Research output: Journal Publication › Article › peer-review

Open Access

15 Citations (Scopus)

Experimental models for posterior capsule opacification research

Wormstone, I. M. & Eldred, J. A., 1 Jan 2016, In: Experimental Eye Research. 142, p. 2-12 11 p.

Research output: Journal Publication › Article › peer-review

Open Access

108 Citations (Scopus)

Rare CFH mutations and early-onset age-related macular degeneration

Hughes, A. E., Meng, W., Bridgett, S. & Bradley, D. T., 1 May 2016, In: Acta Ophthalmologica. 94, 3, p. e247-e248

Research output: Journal Publication › Letter › peer-review

Open Access

9 Citations (Scopus)

Sequence and expression of complement factor H gene cluster variants and their roles in age-related macular degeneration risk

Hughes, A. E., Bridgett, S., Meng, W., Li, M., Curcio, C. A., Stambolian, D. & Bradley, D. T., May 2016, In: Investigative Ophthalmology and Visual Science. 57, 6, p. 2763-2769 7 p.

Research output: Journal Publication › Article › peer-review

Open Access

15 Citations (Scopus)

2015

Ku80 counters oxidative stress-induced DNA damage and cataract formation in the human lens

Smith, A. J. O., Ball, S. S. R., Manzar, K., Bowaterc, R. P. & Wormstone, I. M., 1 Dec 2015, In: Investigative Ophthalmology and Visual Science. 56, 13, p. 7868-7874 7 p.

Research output: Journal Publication › Article › peer-review

Open Access

20 Citations (Scopus)

2014

An in vitro evaluation of the Anew Zephyr open-bag IOL in the prevention of posterior capsule opacification using a human capsular bag model

Eldred, J. A., Spalton, D. J. & Wormstone, I. M., 8 Sept 2014, In: Investigative Ophthalmology and Visual Science. 55, 11, p. 7057-7064 8 p.

Research output: Journal Publication › Article › peer-review

27 Citations (Scopus)

Automated analysis of angle closure from anterior chamber angle images

Baskaran, M., Cheng, J., Perera, S. A., Tun, T. A., Liu, J. & Aung, T., 9 Oct 2014, In: Investigative Ophthalmology and Visual Science. 55, 11, p. 7669-7673 5 p.

Research output: Journal Publication › Article › peer-review

11 Citations (Scopus)

Effect of total lens epithelial cell destruction on intraocular lens fixation in the human capsular bag

Spalton, D. J., Russell, S. L., Evans-Gowing, R., Eldred, J. A. & Wormstone, I. M., Feb 2014, In: Journal of Cataract and Refractive Surgery. 40, 2, p. 306-312 7 p.

Research output: Journal Publication › Article › peer-review

20 Citations (Scopus)

Overweight, obesity, and age-related cataract: A meta-analysis

Pan, C. W. & Lin, Y., May 2014, In: Optometry and Vision Science. 91, 5, p. 478-483 6 p.

Research output: Journal Publication › Article › peer-review

Open Access

36 Citations (Scopus)

2013

Age-related differences in signaling efficiency of human lens cells underpin differential wound healing response rates following cataract surgery

Dawes, L. J., Duncan, G. & Wormstone, I. M., Jan 2013, In: Investigative Ophthalmology and Visual Science. 54, 1, p. 333-342 10 p.

Research output: Journal Publication › Article › peer-review

32 Citations (Scopus)

Serum deprivation can suppress receptor-mediated calcium signaling in pterygial-derived fibroblasts

Fang, C., Illingworth, C. D., Qian, L. & Wormstone, I. M., 2013, In: Investigative Ophthalmology and Visual Science. 54, 7, p. 4563-4570 8 p.

Research output: Journal Publication › Article › peer-review

5 Citations (Scopus)

Sulforaphane can protect lens cells against oxidative stress: Implications for cataract prevention

Liu, H., Smith, A. J. O., Lott, M. C., Bao, Y., Bowater, R. P., Reddan, J. R. & Wormstone, I. M., 2013, In: Investigative Ophthalmology and Visual Science. 54, 8, p. 5236-5248 13 p.

Research output: Journal Publication › Article › peer-review

55 Citations (Scopus)

Validity of a new optic disc grading software for use in clinical and epidemiological research

Tham, Y. C., Cheung, C. Y., Wong, T. Y., Baskaran, M., Liu, J., Lee, B. H., Yin, F., Wong, D. W., Wang, J. J., Mitchell, P., Aung, T. & Cheng, C. Y., Dec 2013, In: Clinical and Experimental Ophthalmology. 41, 9, p. 842-852 11 p.

Research output: Journal Publication › Article › peer-review

9 Citations (Scopus)

2012

A fully human in vitro capsular bag model to permit intraocular lens evaluation

Dawes, L. J., Illingworth, C. D. & Michael Wormstone, I., Jan 2012, In: Investigative Ophthalmology and Visual Science. 53, 1, p. 23-29 7 p.

Research output: Journal Publication › Article › peer-review

23 Citations (Scopus)

A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French population

Meng, W., Butterworth, J., Bradley, D. T., Hughes, A. E., Soler, V., Calvas, P. & Malecaze, F., Dec 2012, In: Investigative Ophthalmology and Visual Science. 53, 13, p. 7983-7988 6 p.

Research output: Journal Publication › Article › peer-review

49 Citations (Scopus)

A linear regression model to differentiate axial myopia from non-axial myopia

Meng, W., Butterworth, J., Malecaze, F. & Calvas, P., Mar 2012, In: Ophthalmic Genetics. 33, 1, p. 53-55 3 p.

Research output: Journal Publication › Letter › peer-review

Open Access

3 Citations (Scopus)

A novel GUCY2D mutation, V933A, causes central areolar choroidal dystrophy

Hughes, A. E., Meng, W., Lotery, A. J. & Bradley, D. T., Jul 2012, In: Investigative Ophthalmology and Visual Science. 53, 8, p. 4748-4753 6 p.

Research output: Journal Publication › Article › peer-review

17 Citations (Scopus)

Genetic factors for choroidal neovascularization associated with high myopia

Leveziel, N., Yu, Y., Reynolds, R., Tai, A., Meng, W., Caillaux, V., Calvas, P., Rosner, B., Malecaze, F., Souied, E. H. & Seddon, J. M., Jul 2012, In: Investigative Ophthalmology and Visual Science. 53, 8, p. 5004-5009 6 p.

Research output: Journal Publication › Article › peer-review

Open Access

49 Citations (Scopus)

Macular degeneration genetics

Bradley, D. T., Meng, W. & Hughes, A. E., Jun 2012, In: Ophthalmology. 119, 6, p. 1287-1288.e1

Research output: Journal Publication › Letter › peer-review

Open Access

1 Citation (Scopus)

MMP2 activity is critical for TGFβ2-induced matrix contraction-implications for fibrosis

Eldred, J. A., Hodgkinson, L. M., Dawes, L. J., Reddan, J. R., Edwards, D. R. & Wormstone, I. M., Jun 2012, In: Investigative Ophthalmology and Visual Science. 53, 7, p. 4085-4098 14 p.

Research output: Journal Publication › Article › peer-review

51 Citations (Scopus)

2011

Axial length of myopia: A review of current research

Meng, W., Butterworth, J., Malecaze, F. & Calvas, P., Mar 2011, In: Ophthalmologica. 225, 3, p. 127-134 8 p.

Research output: Journal Publication › Review article › peer-review

Open Access

183 Citations (Scopus)

Caractérisation du profil biométrique oculaire d'une population myope fort: la myopie forte correspond-elle un phénotype homogne ?

Translated title of the contribution: Characterization of the biometric eye profile of a high myopic population: Does high myopia correspond to a homogenous phenotype?Auriol, S., Butterworth, J., MacÉ, M., Meng, W. & Malecaze, F., Apr 2011, In: Journal Francais d'Ophtalmologie. 34, 4, p. 217-228 12 p.

Research output: Journal Publication › Article › peer-review

1 Citation (Scopus)

Validity of a new computer-aided diagnosis imaging program to quantify nuclear cataract from slit-lamp photographs

Cheung, C. Y. L., Li, H., Lamoureux, E. L., Mitchell, P., Wang, J. J., Tan, A. G., Johari, L. K., Liu, J., Lim, J. H., Aung, T. & Wong, T. Y., Mar 2011, In: Investigative Ophthalmology and Visual Science. 52, 3, p. 1314-1319 6 p.

Research output: Journal Publication › Article › peer-review

19 Citations (Scopus)

2010

ADAM and ADAMTS gene expression in native and wound healing human lens epithelial cells

Hodgkinson, L. M., Wang, L., Duncan, G., Edwards, D. R. & Michael Wormstone, I., 2010, In: Molecular Vision. 16, p. 2765-2776 12 p.

Research output: Journal Publication › Article › peer-review

17 Citations (Scopus)

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