Axial length of myopia: A review of current research

Weihua Meng; Jacqueline Butterworth; François Malecaze; Patrick Calvas

doi:10.1159/000317072

Axial length of myopia: A review of current research

Weihua Meng, Jacqueline Butterworth, François Malecaze, Patrick Calvas

Research output: Journal Publication › Review article › peer-review

158 Citations (Scopus)

Abstract

Myopia, or nearsightedness, is a worldwide common type of refractive error. It is a non-life-threatening disorder with huge social and economic consequences due to its increasing prevalence. Axial length (AL) is the primary determinant of non-syndromic myopia. It is a parameter representing the combination of anterior chamber depth, lens thickness and vitreous chamber depth of the eye. AL can also be treated as an endophenotype of myopia and may provide extra advantages in the investigation of its genetic basis. The study of AL will not only identify the determinants of eye elongation, but also provide aetiological evidence for myopia. The purpose of this review is to outline the current state of AL research. Epidemiological evidence, genetic determinants, the relationship with other eye components and relative animal models of AL are summarised.

Original language	English
Pages (from-to)	127-134
Number of pages	8
Journal	Ophthalmologica
Volume	225
Issue number	3
DOIs	https://doi.org/10.1159/000317072
Publication status	Published - Mar 2011
Externally published	Yes

Keywords

Axial length
Endophenotype
Genetics
Myopia
Refractive error

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000317072

Cite this

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abstract = "Myopia, or nearsightedness, is a worldwide common type of refractive error. It is a non-life-threatening disorder with huge social and economic consequences due to its increasing prevalence. Axial length (AL) is the primary determinant of non-syndromic myopia. It is a parameter representing the combination of anterior chamber depth, lens thickness and vitreous chamber depth of the eye. AL can also be treated as an endophenotype of myopia and may provide extra advantages in the investigation of its genetic basis. The study of AL will not only identify the determinants of eye elongation, but also provide aetiological evidence for myopia. The purpose of this review is to outline the current state of AL research. Epidemiological evidence, genetic determinants, the relationship with other eye components and relative animal models of AL are summarised.",

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AU - Malecaze, François

AU - Calvas, Patrick

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AB - Myopia, or nearsightedness, is a worldwide common type of refractive error. It is a non-life-threatening disorder with huge social and economic consequences due to its increasing prevalence. Axial length (AL) is the primary determinant of non-syndromic myopia. It is a parameter representing the combination of anterior chamber depth, lens thickness and vitreous chamber depth of the eye. AL can also be treated as an endophenotype of myopia and may provide extra advantages in the investigation of its genetic basis. The study of AL will not only identify the determinants of eye elongation, but also provide aetiological evidence for myopia. The purpose of this review is to outline the current state of AL research. Epidemiological evidence, genetic determinants, the relationship with other eye components and relative animal models of AL are summarised.

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Axial length of myopia: A review of current research

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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