Safety and Efficacy of Pneumococcal Vaccination in Pediatric Nephrotic Syndrome

Shamitha Thishakya Goonewardene, Calyn Tang, Loh Teng Hern Tan, Kok Gan Chan, Prithvy Lingham, Learn Han Lee, Bey Hing Goh, Priyia Pusparajah

Research output: Journal PublicationReview articlepeer-review

19 Citations (Scopus)


Nephrotic syndrome affects both children and adults. Idiopathic nephrotic syndrome is reported to be one of the most frequent renal pathologies in childhood. Nephrotic children are at high risk for severe pneumococcal infections as one of the life-threatening complications of nephrotic syndrome due to involvement of the immunosuppressive regimen and the acquired immune deficiency induced by nephrotic syndrome including decreased plasma IgG and low complement system components. Aiming to prevent pneumococcal infection is of paramount importance especially in this era of ever-increasing pneumococcal resistance to penicillins and cephalosporins. The pneumococcal vaccines currently available are inactivated vaccines—the two main forms in use are polysaccharide vaccines and conjugated vaccines. However, the data supporting the use of these vaccines and to guide the timing and dosage recommendations is still limited for nephrotic children. Thus, this review discusses the evidences of immunogenicity and safety profile of both vaccinations on nephrotic patients as well as the effect of nephrotic syndrome treatment on vaccine seroresponses.

Original languageEnglish
Article number339
JournalFrontiers in Pediatrics
Publication statusPublished - 13 Aug 2019
Externally publishedYes


  • efficacy
  • nephrotic
  • pediatric
  • pneumococcal
  • vaccination

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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