Expression of capsaicin receptor (VR1) by myelinated primary afferent neurons in rats

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103 Citations (Scopus)


The expression of capsaicin (VR1) receptor by A-fiber primary afferent neurons has been investigated by double immunohistochemical staining with VR1 and 200 kD neurofilament (NF200; an A-fiber marker) antibodies, and by VR1 immunohistochemical staining in combination with cholera toxin B subunit (CTB; also an A-fiber marker) retrograde tracing. Approximately 30% of the VR1-positive dorsal root ganglion (DRG) neurons were NF200-positive. Intra-sciatic nerve injection of CTB labeled over 30% of the VR1-positive neurons in the L5 DRG. Size frequency distribution analysis revealed that these VR1 and NF200, or VR1 and CTB, double-labeled neurons were predominantly small and medium sized. These results suggest that capsaicin receptors are likely to be expressed by Aδ-fiber neurons as well as C-fiber neurons.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalNeuroscience Letters
Issue number2
Publication statusPublished - 15 Feb 2002
Externally publishedYes


  • Aδ-fibers
  • C-fibers
  • Capsaicin
  • Cholera toxin
  • Dorsal root ganglia
  • Neurofilament
  • VR1 receptor

ASJC Scopus subject areas

  • General Neuroscience


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