Abstract
The expression of capsaicin (VR1) receptor by A-fiber primary afferent neurons has been investigated by double immunohistochemical staining with VR1 and 200 kD neurofilament (NF200; an A-fiber marker) antibodies, and by VR1 immunohistochemical staining in combination with cholera toxin B subunit (CTB; also an A-fiber marker) retrograde tracing. Approximately 30% of the VR1-positive dorsal root ganglion (DRG) neurons were NF200-positive. Intra-sciatic nerve injection of CTB labeled over 30% of the VR1-positive neurons in the L5 DRG. Size frequency distribution analysis revealed that these VR1 and NF200, or VR1 and CTB, double-labeled neurons were predominantly small and medium sized. These results suggest that capsaicin receptors are likely to be expressed by Aδ-fiber neurons as well as C-fiber neurons.
Original language | English |
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Pages (from-to) | 87-90 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 319 |
Issue number | 2 |
DOIs | |
Publication status | Published - 15 Feb 2002 |
Externally published | Yes |
Keywords
- Aδ-fibers
- C-fibers
- Capsaicin
- Cholera toxin
- Dorsal root ganglia
- Neurofilament
- VR1 receptor
ASJC Scopus subject areas
- General Neuroscience