Complete Whole-Genome Sequence of Streptomyces sp. MUM 178J, a Potential Anti-Vibrio Agent

Ke Yan Loo, Loh Teng Hern Tan, Kah Ooi Chua, Priyia Pusparajah, Kok Gan Chan, Learn Han Lee, Jodi Woan Fei Law, Vengadesh Letchumanan

    Research output: Journal PublicationArticlepeer-review

    1 Citation (Scopus)


    Streptomyces sp. is a group of filamentous, Gram-positive bacteria notoriously known for their capabilities in producing bioactive compounds that have been used as novel drugs and lead in drug development. The Streptomyces sp. MUM 178J was isolated from a mangrove forest in Malaysia. This isolate was found to harbor anti-Vibrio properties as its crude extract inhibited the growth of multidrug-resistant Vibrio parahaemolyticus. Therefore, the strain was subjected to whole genome sequencing to unearth its genomic potential. The genome of Streptomyces sp. MUM 178J consists of 6,699,249 bp with a G+C content of 71.3%. 66 tRNA genes and 18 rRNA genes were also predicted to be present within the genome. Further analysis with the bioinformatics tool, antiSMASH (antibiotics & Secondary Metabolite Analysis Shell), detected nine biosynthetic gene clusters displaying more than 70% similarity to known gene clusters, including one associated with melanin production. Melanin has demonstrated antagonistic activity against the growth of members of the Vibrio family, including V. parahaemolyticus. This indicates the potential correlation between the production of melanin and the anti-Vibrio properties of MUM 178J. The availability of the whole genome sequence of Streptomyces sp. MUM 178J allows for future in-depth investigation and potential exploitation of MUM 178J to harvest useful bioactive compounds.

    Original languageEnglish
    Article numbera0000399
    JournalProgress in Microbes and Molecular Biology
    Issue number1
    Publication statusPublished - 7 Feb 2024


    • anti-Vibrio
    • genome
    • mangrove
    • melanin
    • SDG 3 Good health and well-being
    • Streptomyces sp. MUM178J

    ASJC Scopus subject areas

    • Microbiology
    • Molecular Biology
    • Biochemistry, Genetics and Molecular Biology (miscellaneous)
    • Microbiology (medical)


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