Biocompatible waterborne polyurethane-urea elastomer as intelligent anticancer drug release matrix: A sustained drug release study

Ali Bahadur, Aamer Saeed, Shahid Iqbal, Muhammad Shoaib, Muhammad Saif ur Rahman, Muhammad Imran Bashir, Muhammad Asghar, Muhammad Asif Ali, Tahir Mahmood

Research output: Journal PublicationArticlepeer-review

46 Citations (Scopus)

Abstract

Waterborne biodegradable polyurethane–urea (WPUU) elastomer is a revolutionary step in the field of green polymer chemistry. In the present study, emulsifier–free biodegradable WPUU elastomer was synthesized by using lysine as an internal emulsifier as well as a chain extender. WPUU elastomer was used as the stimuli–responsive drug release matrix, loaded by cisplatin as a model anticancer drug. Sustained drug release was studied by changing pH (4.4–7.4), drug release medium, and NCO/OH ratio (3–4). Furthermore, significantly inhibitory effect against Sw–620 cancer lines was observed. Highest cumulative drug release of 71.9% was observed at pH of 7.4 in phosphate buffer saline (PBS) by the system having NCO/OH = 3 for 250 h. The oxidative degradation was evaluated in CoCl2/H2O2 solution. Mechanical properties were tested by using the mechanical testing machine. The synthesized WPUU films exhibited high thermal stability, hardness, tensile strength and hydrophobicity.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalReactive and Functional Polymers
Volume119
DOIs
Publication statusPublished - Oct 2017
Externally publishedYes

Keywords

  • Cisplatin anticancer drug
  • Lysine
  • Polyurethane–urea elastomer
  • Stimuli–responsive
  • Sustain release

ASJC Scopus subject areas

  • General Chemistry
  • Environmental Chemistry
  • Biochemistry
  • General Chemical Engineering
  • Polymers and Plastics
  • Materials Chemistry

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