Biocompatible waterborne polyurethane-urea elastomer as intelligent anticancer drug release matrix: A sustained drug release study

Ali Bahadur; Aamer Saeed; Shahid Iqbal; Muhammad Shoaib; Muhammad Saif ur Rahman; Muhammad Imran Bashir; Muhammad Asghar; Muhammad Asif Ali; Tahir Mahmood

doi:10.1016/j.reactfunctpolym.2017.08.001

Biocompatible waterborne polyurethane-urea elastomer as intelligent anticancer drug release matrix: A sustained drug release study

Ali Bahadur, Aamer Saeed, Shahid Iqbal, Muhammad Shoaib, Muhammad Saif ur Rahman, Muhammad Imran Bashir, Muhammad Asghar, Muhammad Asif Ali, Tahir Mahmood

Research output: Journal Publication › Article › peer-review

44 Citations (Scopus)

Abstract

Waterborne biodegradable polyurethane–urea (WPUU) elastomer is a revolutionary step in the field of green polymer chemistry. In the present study, emulsifier–free biodegradable WPUU elastomer was synthesized by using lysine as an internal emulsifier as well as a chain extender. WPUU elastomer was used as the stimuli–responsive drug release matrix, loaded by cisplatin as a model anticancer drug. Sustained drug release was studied by changing pH (4.4–7.4), drug release medium, and NCO/OH ratio (3–4). Furthermore, significantly inhibitory effect against Sw–620 cancer lines was observed. Highest cumulative drug release of 71.9% was observed at pH of 7.4 in phosphate buffer saline (PBS) by the system having NCO/OH = 3 for 250 h. The oxidative degradation was evaluated in CoCl₂/H₂O₂ solution. Mechanical properties were tested by using the mechanical testing machine. The synthesized WPUU films exhibited high thermal stability, hardness, tensile strength and hydrophobicity.

Original language	English
Pages (from-to)	57-63
Number of pages	7
Journal	Reactive and Functional Polymers
Volume	119
DOIs	https://doi.org/10.1016/j.reactfunctpolym.2017.08.001
Publication status	Published - Oct 2017
Externally published	Yes

Keywords

Cisplatin anticancer drug
Lysine
Polyurethane–urea elastomer
Stimuli–responsive
Sustain release

ASJC Scopus subject areas

General Chemistry
Environmental Chemistry
Biochemistry
General Chemical Engineering
Polymers and Plastics
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.reactfunctpolym.2017.08.001

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title = "Biocompatible waterborne polyurethane-urea elastomer as intelligent anticancer drug release matrix: A sustained drug release study",

abstract = "Waterborne biodegradable polyurethane–urea (WPUU) elastomer is a revolutionary step in the field of green polymer chemistry. In the present study, emulsifier–free biodegradable WPUU elastomer was synthesized by using lysine as an internal emulsifier as well as a chain extender. WPUU elastomer was used as the stimuli–responsive drug release matrix, loaded by cisplatin as a model anticancer drug. Sustained drug release was studied by changing pH (4.4–7.4), drug release medium, and NCO/OH ratio (3–4). Furthermore, significantly inhibitory effect against Sw–620 cancer lines was observed. Highest cumulative drug release of 71.9% was observed at pH of 7.4 in phosphate buffer saline (PBS) by the system having NCO/OH = 3 for 250 h. The oxidative degradation was evaluated in CoCl2/H2O2 solution. Mechanical properties were tested by using the mechanical testing machine. The synthesized WPUU films exhibited high thermal stability, hardness, tensile strength and hydrophobicity.",

keywords = "Cisplatin anticancer drug, Lysine, Polyurethane–urea elastomer, Stimuli–responsive, Sustain release",

author = "Ali Bahadur and Aamer Saeed and Shahid Iqbal and Muhammad Shoaib and Rahman, {Muhammad Saif ur} and Bashir, {Muhammad Imran} and Muhammad Asghar and Ali, {Muhammad Asif} and Tahir Mahmood",

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year = "2017",

month = oct,

doi = "10.1016/j.reactfunctpolym.2017.08.001",

language = "English",

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T2 - A sustained drug release study

AU - Bahadur, Ali

AU - Saeed, Aamer

AU - Iqbal, Shahid

AU - Shoaib, Muhammad

AU - Rahman, Muhammad Saif ur

AU - Bashir, Muhammad Imran

AU - Asghar, Muhammad

AU - Ali, Muhammad Asif

AU - Mahmood, Tahir

PY - 2017/10

Y1 - 2017/10

N2 - Waterborne biodegradable polyurethane–urea (WPUU) elastomer is a revolutionary step in the field of green polymer chemistry. In the present study, emulsifier–free biodegradable WPUU elastomer was synthesized by using lysine as an internal emulsifier as well as a chain extender. WPUU elastomer was used as the stimuli–responsive drug release matrix, loaded by cisplatin as a model anticancer drug. Sustained drug release was studied by changing pH (4.4–7.4), drug release medium, and NCO/OH ratio (3–4). Furthermore, significantly inhibitory effect against Sw–620 cancer lines was observed. Highest cumulative drug release of 71.9% was observed at pH of 7.4 in phosphate buffer saline (PBS) by the system having NCO/OH = 3 for 250 h. The oxidative degradation was evaluated in CoCl2/H2O2 solution. Mechanical properties were tested by using the mechanical testing machine. The synthesized WPUU films exhibited high thermal stability, hardness, tensile strength and hydrophobicity.

AB - Waterborne biodegradable polyurethane–urea (WPUU) elastomer is a revolutionary step in the field of green polymer chemistry. In the present study, emulsifier–free biodegradable WPUU elastomer was synthesized by using lysine as an internal emulsifier as well as a chain extender. WPUU elastomer was used as the stimuli–responsive drug release matrix, loaded by cisplatin as a model anticancer drug. Sustained drug release was studied by changing pH (4.4–7.4), drug release medium, and NCO/OH ratio (3–4). Furthermore, significantly inhibitory effect against Sw–620 cancer lines was observed. Highest cumulative drug release of 71.9% was observed at pH of 7.4 in phosphate buffer saline (PBS) by the system having NCO/OH = 3 for 250 h. The oxidative degradation was evaluated in CoCl2/H2O2 solution. Mechanical properties were tested by using the mechanical testing machine. The synthesized WPUU films exhibited high thermal stability, hardness, tensile strength and hydrophobicity.

KW - Cisplatin anticancer drug

KW - Lysine

KW - Polyurethane–urea elastomer

KW - Stimuli–responsive

KW - Sustain release

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JF - Reactive and Functional Polymers

ER -

Biocompatible waterborne polyurethane-urea elastomer as intelligent anticancer drug release matrix: A sustained drug release study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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