A Keystone Gut Bacterium Christensenella minuta—A Potential Biotherapeutic Agent for Obesity and Associated Metabolic Diseases

Wei Shan Ang, Jodi Woan Fei Law, Vengadesh Letchumanan, Kar Wai Hong, Sunny Hei Wong, Nurul Syakima Ab Mutalib, Kok Gan Chan, Learn Han Lee, Loh Teng Hern Tan

Research output: Journal PublicationReview articlepeer-review

10 Citations (Scopus)

Abstract

A new next-generation probiotic, Christensenella minuta was first discovered in 2012 from healthy human stool and described under the phylum Firmicutes. C. minuta is a subdominant commensal bacterium with highly heritable properties that exhibits mutual interactions with other heritable microbiomes, and its relative abundance is positively correlated with the lean host phenotype associated with a low BMI index. It has been the subject of numerous studies, owing to its potential health benefits. This article reviews the evidence from various studies of C. minuta interventions using animal models for managing metabolic diseases, such as obesity, inflammatory bowel disease, and type 2 diabetes, characterized by gut microbiota dysbiosis and disruption of host metabolism. Notably, more studies have presented the complex interaction between C. minuta and host metabolism when it comes to metabolic health. Therefore, C. minuta could be a potential candidate for innovative microbiome-based biotherapy via fecal microbiota transplantation or oral administration. However, the detailed underlying mechanism of action requires further investigation.

Original languageEnglish
Article number2485
JournalFoods
Volume12
Issue number13
DOIs
Publication statusPublished - Jul 2023
Externally publishedYes

Keywords

  • Christensenella minuta
  • inflammatory bowel disease
  • metabolic diseases
  • next-generation probiotic
  • obesity

ASJC Scopus subject areas

  • Food Science
  • Microbiology
  • Health(social science)
  • Health Professions (miscellaneous)
  • Plant Science

Fingerprint

Dive into the research topics of 'A Keystone Gut Bacterium Christensenella minuta—A Potential Biotherapeutic Agent for Obesity and Associated Metabolic Diseases'. Together they form a unique fingerprint.

Cite this