Whole-genome sequence of bioactive streptomycete derived from mangrove forest in Malaysia, Streptomyces sp. MUSC 14

Hooi Leng Ser; Loh Teng Hern Tan; Wen Si Tan; Wai Fong Yin; Kok Gan Chan

doi:10.36877/pmmb.a0000195

Whole-genome sequence of bioactive streptomycete derived from mangrove forest in Malaysia, Streptomyces sp. MUSC 14

Hooi Leng Ser, Loh Teng Hern Tan, Wen Si Tan, Wai Fong Yin, Kok Gan Chan

Research output: Journal Publication › Article › peer-review

14 Citations (Scopus)

Abstract

The contribution of streptomycetes to human health is undeniably important and significant, given that these filamentous microbes can produce interesting compounds that can be used to cure deadly infections and even cancer. Isolated from the east coast of Peninsular Malaysia, Streptomyces sp. MUSC 14 has shown significant antioxidant capacity. The current study explores the genomic potential of MUSC 14 via a genome mining approach. The genome size of MUSC 14 is 10,274,825 bp with G + C content of 71.3 %. AntiSMASH analysis revealed a total of nine biosynthetic gene clusters (with more than 80 % similarities to known gene clusters). This information serves as an important foundation for subsequent studies, particularly the purification and isolation of bioactive compounds by genetic manipulation techniques.

Original language	English
Article number	a0000195
Journal	Progress in Microbes and Molecular Biology
Volume	4
Issue number	1
DOIs	https://doi.org/10.36877/pmmb.a0000195
Publication status	Published - 8 Feb 2021
Externally published	Yes

Keywords

MUSC 14
Streptomyces
actinobacteria
antioxidant
genome
mangrove

ASJC Scopus subject areas

Molecular Biology
Microbiology (medical)
Microbiology
Biochemistry, Genetics and Molecular Biology (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.36877/pmmb.a0000195

Cite this

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title = "Whole-genome sequence of bioactive streptomycete derived from mangrove forest in Malaysia, Streptomyces sp. MUSC 14",

abstract = "The contribution of streptomycetes to human health is undeniably important and significant, given that these filamentous microbes can produce interesting compounds that can be used to cure deadly infections and even cancer. Isolated from the east coast of Peninsular Malaysia, Streptomyces sp. MUSC 14 has shown significant antioxidant capacity. The current study explores the genomic potential of MUSC 14 via a genome mining approach. The genome size of MUSC 14 is 10,274,825 bp with G + C content of 71.3 %. AntiSMASH analysis revealed a total of nine biosynthetic gene clusters (with more than 80 % similarities to known gene clusters). This information serves as an important foundation for subsequent studies, particularly the purification and isolation of bioactive compounds by genetic manipulation techniques.",

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doi = "10.36877/pmmb.a0000195",

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volume = "4",

journal = "Progress in Microbes and Molecular Biology",

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AU - Ser, Hooi Leng

AU - Tan, Loh Teng Hern

AU - Tan, Wen Si

AU - Yin, Wai Fong

AU - Chan, Kok Gan

PY - 2021/2/8

Y1 - 2021/2/8

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AB - The contribution of streptomycetes to human health is undeniably important and significant, given that these filamentous microbes can produce interesting compounds that can be used to cure deadly infections and even cancer. Isolated from the east coast of Peninsular Malaysia, Streptomyces sp. MUSC 14 has shown significant antioxidant capacity. The current study explores the genomic potential of MUSC 14 via a genome mining approach. The genome size of MUSC 14 is 10,274,825 bp with G + C content of 71.3 %. AntiSMASH analysis revealed a total of nine biosynthetic gene clusters (with more than 80 % similarities to known gene clusters). This information serves as an important foundation for subsequent studies, particularly the purification and isolation of bioactive compounds by genetic manipulation techniques.

KW - MUSC 14

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KW - actinobacteria

KW - antioxidant

KW - genome

KW - mangrove

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Whole-genome sequence of bioactive streptomycete derived from mangrove forest in Malaysia, Streptomyces sp. MUSC 14

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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