Unleashing the Power of Artificial Intelligence-Driven Drug Discovery in Streptomyces

Wei Shan Ang, Jodi Woan Fei Law, Yatinesh Kumari, Vengadesh Letchumanan, Loh Teng Hern Tan

    Research output: Journal PublicationReview articlepeer-review

    Abstract

    The rise of antibiotic resistance has created an urgent need for the discovery of new antibiotic compounds. Streptomycin, the first antibiotic isolated from Streptomyces sp., paved the way for discovering other antibiotics for combating bacterial infections. By exploring the genome-based biosynthetic potential of various Streptomyces species, a vast array of secondary metabolites with potential therapeutic applications can be identified, contributing a transformative impact on the field of medicine. However, conventional screening approaches on novel natural products (NPs) from Streptomyces sp. have entered a bottleneck due to inefficiency. Fortunately, artificial intelligence (AI) and machine learning (ML) models enable rapid exploration and prediction of potential antibiotic compounds, increasing the probability of discovering new antibacterial compounds. AI-driven drug discovery in Streptomyces sp. represents a paradigm shift in the future quest for novel pharmaceutical agents. Various ML models have been developed and applied in different practical applications. Overall, the ML model is trained using input data and generates outcomes based on prediction output. This review discusses the continued potential of Streptomyces sp. as a source of novel NPs, along with the application of ML throughout the NP drug discovery pipeline involving genome mining, biological activities prediction, and optimization compound production in Streptomyces microbial systems.

    Original languageEnglish
    Article numbera0000453
    JournalProgress in Microbes and Molecular Biology
    Volume7
    Issue number1
    DOIs
    Publication statusPublished - 7 Feb 2024

    Keywords

    • Artificial Intelligence
    • Drug discovery
    • Machine Learning
    • Natural products
    • SDG 3 Good health and well-being
    • Secondary metabolites
    • Streptomyces

    ASJC Scopus subject areas

    • Microbiology
    • Molecular Biology
    • Biochemistry, Genetics and Molecular Biology (miscellaneous)
    • Microbiology (medical)

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