Microbial cancer therapeutics: A promising approach

Deepti Diwan; Lei Cheng; Zeba Usmani; Minaxi Sharma; Nicola Holden; Nicholas Willoughby; Neelam Sangwan; Rama Raju Baadhe; Chenchen Liu; Vijai Kumar Gupta

doi:10.1016/j.semcancer.2021.05.003

Microbial cancer therapeutics: A promising approach

Deepti Diwan, Lei Cheng, Zeba Usmani, Minaxi Sharma, Nicola Holden, Nicholas Willoughby, Neelam Sangwan, Rama Raju Baadhe, Chenchen Liu, Vijai Kumar Gupta

Research output: Journal Publication › Review article › peer-review

14 Citations (Scopus)

Abstract

The success of conventional cancer therapeutics is hindered by associated dreadful side-effects of antibiotic resistance and the dearth of antitumor drugs' selectivity and specificity. Hence, the conceptual evolution of anti-cancerous therapeutic agents that selectively target cancer cells without impacting the healthy cells or tissues, has led to a new wave of scientific interest in microbial-derived bioactive molecules. Such strategic solutions may pave the way to surmount the shortcomings of conventional therapies and raise the potential and hope for the cure of wide range of cancer in a selective manner. This review aims to provide a comprehensive summary of anti-carcinogenic properties and underlying mechanisms of bioactive molecules of microbial origin, and discuss the current challenges and effective therapeutic application of combinatorial strategies to attain minimal systemic side-effects.

Original language	English
Pages (from-to)	931-950
Number of pages	20
Journal	Seminars in Cancer Biology
Volume	86
DOIs	https://doi.org/10.1016/j.semcancer.2021.05.003
Publication status	Published - Nov 2022
Externally published	Yes

Keywords

Bacteriocins
Bioactive molecules
Cancer
Genetically engineered microbes
Microbial therapy

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.semcancer.2021.05.003

Cite this

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title = "Microbial cancer therapeutics: A promising approach",

abstract = "The success of conventional cancer therapeutics is hindered by associated dreadful side-effects of antibiotic resistance and the dearth of antitumor drugs' selectivity and specificity. Hence, the conceptual evolution of anti-cancerous therapeutic agents that selectively target cancer cells without impacting the healthy cells or tissues, has led to a new wave of scientific interest in microbial-derived bioactive molecules. Such strategic solutions may pave the way to surmount the shortcomings of conventional therapies and raise the potential and hope for the cure of wide range of cancer in a selective manner. This review aims to provide a comprehensive summary of anti-carcinogenic properties and underlying mechanisms of bioactive molecules of microbial origin, and discuss the current challenges and effective therapeutic application of combinatorial strategies to attain minimal systemic side-effects.",

keywords = "Bacteriocins, Bioactive molecules, Cancer, Genetically engineered microbes, Microbial therapy",

author = "Deepti Diwan and Lei Cheng and Zeba Usmani and Minaxi Sharma and Nicola Holden and Nicholas Willoughby and Neelam Sangwan and Baadhe, {Rama Raju} and Chenchen Liu and Gupta, {Vijai Kumar}",

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year = "2022",

month = nov,

doi = "10.1016/j.semcancer.2021.05.003",

language = "English",

volume = "86",

pages = "931--950",

journal = "Seminars in Cancer Biology",

issn = "1044-579X",

publisher = "Academic Press",

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TY - JOUR

T1 - Microbial cancer therapeutics

T2 - A promising approach

AU - Diwan, Deepti

AU - Cheng, Lei

AU - Usmani, Zeba

AU - Sharma, Minaxi

AU - Holden, Nicola

AU - Willoughby, Nicholas

AU - Sangwan, Neelam

AU - Baadhe, Rama Raju

AU - Liu, Chenchen

AU - Gupta, Vijai Kumar

PY - 2022/11

Y1 - 2022/11

N2 - The success of conventional cancer therapeutics is hindered by associated dreadful side-effects of antibiotic resistance and the dearth of antitumor drugs' selectivity and specificity. Hence, the conceptual evolution of anti-cancerous therapeutic agents that selectively target cancer cells without impacting the healthy cells or tissues, has led to a new wave of scientific interest in microbial-derived bioactive molecules. Such strategic solutions may pave the way to surmount the shortcomings of conventional therapies and raise the potential and hope for the cure of wide range of cancer in a selective manner. This review aims to provide a comprehensive summary of anti-carcinogenic properties and underlying mechanisms of bioactive molecules of microbial origin, and discuss the current challenges and effective therapeutic application of combinatorial strategies to attain minimal systemic side-effects.

AB - The success of conventional cancer therapeutics is hindered by associated dreadful side-effects of antibiotic resistance and the dearth of antitumor drugs' selectivity and specificity. Hence, the conceptual evolution of anti-cancerous therapeutic agents that selectively target cancer cells without impacting the healthy cells or tissues, has led to a new wave of scientific interest in microbial-derived bioactive molecules. Such strategic solutions may pave the way to surmount the shortcomings of conventional therapies and raise the potential and hope for the cure of wide range of cancer in a selective manner. This review aims to provide a comprehensive summary of anti-carcinogenic properties and underlying mechanisms of bioactive molecules of microbial origin, and discuss the current challenges and effective therapeutic application of combinatorial strategies to attain minimal systemic side-effects.

KW - Bacteriocins

KW - Bioactive molecules

KW - Cancer

KW - Genetically engineered microbes

KW - Microbial therapy

UR - http://www.scopus.com/inward/record.url?scp=85106249930&partnerID=8YFLogxK

U2 - 10.1016/j.semcancer.2021.05.003

DO - 10.1016/j.semcancer.2021.05.003

M3 - Review article

C2 - 33979677

AN - SCOPUS:85106249930

SN - 1044-579X

VL - 86

SP - 931

EP - 950

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

ER -

Microbial cancer therapeutics: A promising approach

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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