Genipin-enriched chitosan-Zein nanoparticles for improved curcumin encapsulation

Lingling Sha, Husnain Raza, Chengsheng Jia, Imran Mahmood Khan, Huqing Yang, Gang Chen

Research output: Journal PublicationArticlepeer-review

2 Citations (Scopus)
Plum Print visual indicator of research metrics
  • Citations
    • Citation Indexes: 2
  • Captures
    • Readers: 3
see details

Abstract

Polysaccharide-protein nanocomplexes are considered one of the desired systems to encapsulate bioactive compounds. The study prepared chitosan (CS)/genipin (GP)/zein nanoparticles with chemical cross-linkage for encapsulating and releasing curcumin. Fourier transform infrared spectra demonstrated that cross-linkage between molecules was attributed to electrostatic interactions and the formation of amido bonds and hydrogen bonding. Transmission electron microscopy showed that all prepared nanoparticles showed a spherical morphology. Particularly, cinnamaldehyde screening –NH2 groups in CS significantly reduced the encapsulation efficiency of nanoparticles, demonstrating the significant role of the –NH2 group in CS-coated zein nanoparticles. Additionally, the encapsulation efficiency was largely increased to 82.3 % at the ratio of CS/GP/zein (w/w, 20:1:100), compared with 38.4 % using zein as a single encapsulation for curcumin. In vitro digestion, the addition of GP and CS decreased the release of curcumin from 84.8 % to 57.1 % after the initial digestion of 2 h. The GP/CS/zein particles retained 12 % of curcumin after 6- h of digestion, indicating the improvements in encapsulation efficiency and release properties.

Original languageEnglish
Article number138555
JournalInternational Journal of Biological Macromolecules
Volume288
DOIs
Publication statusPublished - Feb 2025

Keywords

  • Chitosan
  • Encapsulation
  • Genipin
  • Nanoparticles
  • Zein

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology

Fingerprint

Dive into the research topics of 'Genipin-enriched chitosan-Zein nanoparticles for improved curcumin encapsulation'. Together they form a unique fingerprint.

Cite this

Sha, L., Raza, H., Jia, C., Khan, I. M., Yang, H., & Chen, G. (2025). Genipin-enriched chitosan-Zein nanoparticles for improved curcumin encapsulation. International Journal of Biological Macromolecules, 288, Article 138555. https://doi.org/10.1016/j.ijbiomac.2024.138555