TY - JOUR
T1 - Drug nanodelivery systems based on natural polysaccharides against different diseases
AU - Rehman, Abdur
AU - Jafari, Seid Mahdi
AU - Tong, Qunyi
AU - Riaz, Tahreem
AU - Assadpour, Elham
AU - Aadil, Rana Muhammad
AU - Niazi, Sobia
AU - Khan, Imran Mahmood
AU - Shehzad, Qayyum
AU - Ali, Ahmad
AU - Khan, Sohail
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/10
Y1 - 2020/10
N2 - Drug nanodelivery systems (DNDSs) are fascinated cargos to achieve outstanding therapeutic results of various drugs or natural bioactive compounds owing to their unique structures. The efficiency of several pharmaceutical drugs or natural bioactive ingredients is restricted because of their week bioavailability, poor bioaccessibility and pharmacokinetics after orally pathways. In order to handle such constraints, usage of native/natural polysaccharides (NPLS) in fabrication of DNDSs has gained more popularity in the arena of nanotechnology for controlled drug delivery to enhance safety, biocompatibility, better retention time, bioavailability, lower toxicity and enhanced permeability. The main commonly used NPLS in nanoencapsulation systems include chitosan, pectin, alginates, cellulose, starches, and gums recognized as potential materials for fabrication of cargos. Herein, this review is centered on different polysaccharide-based nanocarriers including nanoemulsions, nanohydrogels, nanoliposomes, nanoparticles and nanofibers, which have already served as encouraging candidates for entrapment of therapeutic drugs as well as for their sustained controlled release. Furthermore, the current article explicitly offers comprehensive details regarding application of NPLS-based nanocarriers encapsulating several drugs intended for the handling of numerous disorders, including diabetes, cancer, HIV, malaria, cardiovascular and respiratory as well as skin diseases.
AB - Drug nanodelivery systems (DNDSs) are fascinated cargos to achieve outstanding therapeutic results of various drugs or natural bioactive compounds owing to their unique structures. The efficiency of several pharmaceutical drugs or natural bioactive ingredients is restricted because of their week bioavailability, poor bioaccessibility and pharmacokinetics after orally pathways. In order to handle such constraints, usage of native/natural polysaccharides (NPLS) in fabrication of DNDSs has gained more popularity in the arena of nanotechnology for controlled drug delivery to enhance safety, biocompatibility, better retention time, bioavailability, lower toxicity and enhanced permeability. The main commonly used NPLS in nanoencapsulation systems include chitosan, pectin, alginates, cellulose, starches, and gums recognized as potential materials for fabrication of cargos. Herein, this review is centered on different polysaccharide-based nanocarriers including nanoemulsions, nanohydrogels, nanoliposomes, nanoparticles and nanofibers, which have already served as encouraging candidates for entrapment of therapeutic drugs as well as for their sustained controlled release. Furthermore, the current article explicitly offers comprehensive details regarding application of NPLS-based nanocarriers encapsulating several drugs intended for the handling of numerous disorders, including diabetes, cancer, HIV, malaria, cardiovascular and respiratory as well as skin diseases.
KW - Cancer
KW - Cardiovascular
KW - Diabetes
KW - Diagnosis
KW - Drugs
KW - HIV
KW - Malaria
KW - Nanocarriers
KW - Natural polysaccharides
KW - Respiratory diseases
KW - Skin diseases
UR - http://www.scopus.com/inward/record.url?scp=85090967075&partnerID=8YFLogxK
U2 - 10.1016/j.cis.2020.102251
DO - 10.1016/j.cis.2020.102251
M3 - Review article
C2 - 32949812
AN - SCOPUS:85090967075
SN - 0001-8686
VL - 284
JO - Advances in Colloid and Interface Science
JF - Advances in Colloid and Interface Science
M1 - 102251
ER -
