TY - JOUR
T1 - A general strategy to synthesis chitosan oligosaccharide-O-Terpenol derivatives with antibacterial properties
AU - Yue, Lin
AU - Zheng, Meihong
AU - Wang, Min
AU - Khan, Imran Mahmood
AU - Wang, Bin
AU - Ma, Xiaoyuan
AU - Peng, Chifang
AU - Wang, Zhouping
AU - Xia, Wenshui
N1 - Publisher Copyright:
© 2021
PY - 2021/5
Y1 - 2021/5
N2 - The objectives of the present study are to synthesize a series of chitosan oligosaccharide-O-Terpenol (COS–O-Ter) derivatives and their implication to evaluate in vitro antibacterial activity. Herein, a general strategy is described for preparing COS–O-Ter derivatives, including substitution and deprotection reactions. The structures of COS–O-Ter derivatives were characterized by FT-IR, 1H NMR, XRD, TGA, and elemental analysis. COS–O-Ter derivatives revealed the excellent solubility and in vitro antibacterial activity. Moreover, their antibacterial activities were more sensitive to Staphylococcus aureus (S. aureus) than Escherichia coli (E. coli) indicating the effective potential application of COS–O-Ter derivatives as natural antibacterial agents. The aforementioned study opens a pave to expand the application scope of COS and its derivatives in the food and pharmaceutical industries.
AB - The objectives of the present study are to synthesize a series of chitosan oligosaccharide-O-Terpenol (COS–O-Ter) derivatives and their implication to evaluate in vitro antibacterial activity. Herein, a general strategy is described for preparing COS–O-Ter derivatives, including substitution and deprotection reactions. The structures of COS–O-Ter derivatives were characterized by FT-IR, 1H NMR, XRD, TGA, and elemental analysis. COS–O-Ter derivatives revealed the excellent solubility and in vitro antibacterial activity. Moreover, their antibacterial activities were more sensitive to Staphylococcus aureus (S. aureus) than Escherichia coli (E. coli) indicating the effective potential application of COS–O-Ter derivatives as natural antibacterial agents. The aforementioned study opens a pave to expand the application scope of COS and its derivatives in the food and pharmaceutical industries.
KW - Antibacterial activity
KW - Chemical modification
KW - Chitosan oligosaccharide
KW - Terpenol
UR - http://www.scopus.com/inward/record.url?scp=85104105527&partnerID=8YFLogxK
U2 - 10.1016/j.carres.2021.108315
DO - 10.1016/j.carres.2021.108315
M3 - Article
C2 - 33865180
AN - SCOPUS:85104105527
SN - 0008-6215
VL - 503
JO - Carbohydrate Research
JF - Carbohydrate Research
M1 - 108315
ER -