A general strategy to synthesis chitosan oligosaccharide-O-Terpenol derivatives with antibacterial properties

Lin Yue, Meihong Zheng, Min Wang, Imran Mahmood Khan, Bin Wang, Xiaoyuan Ma, Chifang Peng, Zhouping Wang, Wenshui Xia

Research output: Journal PublicationArticlepeer-review

12 Citations (Scopus)

Abstract

The objectives of the present study are to synthesize a series of chitosan oligosaccharide-O-Terpenol (COS–O-Ter) derivatives and their implication to evaluate in vitro antibacterial activity. Herein, a general strategy is described for preparing COS–O-Ter derivatives, including substitution and deprotection reactions. The structures of COS–O-Ter derivatives were characterized by FT-IR, 1H NMR, XRD, TGA, and elemental analysis. COS–O-Ter derivatives revealed the excellent solubility and in vitro antibacterial activity. Moreover, their antibacterial activities were more sensitive to Staphylococcus aureus (S. aureus) than Escherichia coli (E. coli) indicating the effective potential application of COS–O-Ter derivatives as natural antibacterial agents. The aforementioned study opens a pave to expand the application scope of COS and its derivatives in the food and pharmaceutical industries.

Original languageEnglish
Article number108315
JournalCarbohydrate Research
Volume503
DOIs
Publication statusPublished - May 2021
Externally publishedYes

Keywords

  • Antibacterial activity
  • Chemical modification
  • Chitosan oligosaccharide
  • Terpenol

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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