Wheezing, allergy, and parasite infection in children in urban and rural ethiopia

Damtew Dagoye, Zegaye Bekele, Kifle Woldemichael, Hailu Nida, Meselech Yimam, Andy Hall, Andrea J. Venn, John R. Britton, Richard Hubbard, Sarah A. Lewis

Research output: Journal PublicationArticlepeer-review

153 Citations (Scopus)

Abstract

Epidemiological studies in developing countries suggest that intestinal parasite infection may reduce the risk of asthma. Because this evidence is all derived from adults and older children, we have investigated the relation between parasite infection, wheezing, and allergen skin sensitization in nested case-control studies drawn from a survey of 7,155 children aged 1 to 4 years living in urban and rural areas of Jimma, Ethiopia. Infection with parasites was common, predominantly with Trichuris (54%), Ascaris (38%), and hookworm (10%). Wheezing in the past year was significantly more prevalent in urban (4.4%) than rural children (2.0%), and was less prevalent in those infected with Ascaris (age, sex, and urban/rural adjusted odds ratio, 0.5; 95% confidence interval, 0.3 to 0.9), particularly in relation to high-intensity infection. Similar, although nonsignificant, associations were found for hookworm (adjusted odds ratio, 0.6; 95% confidence interval, 0.2 to 1.8), but there was no suggestion of any relation to Trichuris infection. Dermatophagoides pteronyssinus and cockroach (Blattella germanica) skin sensitization was more prevalent in rural than urban children, and was unrelated to wheeze. We conclude that Ascaris and possibly hookworm infection protects against wheeze in young Ethiopian children, and that this effect is not mediated by inhibition of allergen sensitization.

Original languageEnglish
Pages (from-to)1369-1373
Number of pages5
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume167
Issue number10
DOIs
Publication statusPublished - 15 May 2003
Externally publishedYes

Keywords

  • Atopy
  • Parasites
  • Wheeze

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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