The Current State of Knowledge in Biological Properties of Cirsimaritin

Taoufiq Benali, Imane Jaouadi, Rokia Ghchime, Nasreddine El Omari, Kaoutar Harboul, Khalil Hammani, Maksim Rebezov, Mohammad Ali Shariati, Mohammad S. Mubarak, Jesus Simal-Gandara, Gokhan Zengin, Moon Nyeo Park, Bonglee Kim, Shafi Mahmud, Learn Han Lee, Abdelhakim Bouyahya

Research output: Journal PublicationReview articlepeer-review

10 Citations (Scopus)


The search for natural plant-based products as new pharmacological alternatives to treat various human pathologies has taken on great importance for researchers and research laboratories. In this context, research has intensified to extract and identify natural molecules endowed with biological effects. The objective of this study is to review the source and pharmacological properties of cirsimaritin. The identification and isolation of this flavonoid from various natural sources, including medicinal plants such as Artemisia judaica, Cirsium japonicum, Lithocarpus dealbatus, Microtea debilis, and Ocimum sanctum, has been carried out and verified using different spectral techniques. Biological effect investigations are carried out with a wide variety of experimental models in vitro and in vivo and laboratory techniques. The results of these research works showed the biological properties of cirsimaritin including anticancer, antimicrobial, antidiabetic, antiparasitic, antioxidant, and anti-inflammatory effects. The mechanisms involved in the multiple activities of this molecule are diverse and include sub-cellular, cellular, and molecular levels. Indeed, this bioactive induces anti-inflammatory and antiproliferative effects by inhibiting cell membrane receptors, interference with signaling pathways, and inhibiting transcriptional factors such as Nf-κB involved in cell promotion and proliferation. In the light of these results, cirsimaritin appears as a promising and viable alternative natural bioactive drug to treat many pathological conditions.

Original languageEnglish
Article number1842
Issue number9
Publication statusPublished - Sept 2022
Externally publishedYes


  • anticancer activity
  • apoptosis
  • bioactive compound
  • pharmacodynamic action

ASJC Scopus subject areas

  • Food Science
  • Physiology
  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology


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