Synergistic enhancement of ultrahigh SERS activity via Cu2O@Ag Core-Shell structure for accurate label-free identification of breast tumor subtypes

Yujiao Xie, Chao Chen, Chenguang Zhang, Lei Xu, Zihou Li, Wenzhi Ren, Xiawei Xu, Yong Ren, Jie Lin, Aiguo Wu

Research output: Journal PublicationArticlepeer-review

5 Citations (Scopus)

Abstract

Conventional methodology for accurate identification of breast tumor subtypes is complex and time-consuming. Label-free SERS (surface-enhanced Raman scattering) enables rapid detection of biomolecules and provides intrinsic fingerprint information of analytes. Exploring reliable SERS bioprobes with high sensitivity and repeatability is essential for efficient typing of cancer cells. In this study, a novel core-shell noble metal-semiconductor Cu2O@Ag heterostructure with uniform morphology and outstanding SERS activity for label-free detection has been proposed. The Cu2O@Ag SERS substrates exhibit exceptional sensitivity to detect 4 nitrophenthiol (4NTP) at extreme low concentration (10−15 M), and the SERS spectra demonstrate excellent selectivity and repeatability (RSD ≈ 8.84%). The enhancement mechanism is attributed to the synergistic enhancement of photoinduced charge transfer and boosted surface plasmon resonance effect, confirmed by reduced fluorescence lifetime of methylene blue on SERS substrates and enhanced electromagnetic field intensity via finite-difference time-domain computational simulation. The ultrahigh sensitivity and good signal stability endow Cu2O@Ag SERS bioprobe potential for accurate detection of four breast cancer cells subtypes. The rich fingerprint information from SERS spectra is processed using linear differentiation analysis, revealing a high accuracy of 93.3% for subtypes classification. These results demonstrate an excellent SERS bioprobe with high sensitivity and repeatability for precision diagnosis has been developed.

Original languageEnglish
Article number102140
JournalNano Today
Volume54
DOIs
Publication statusPublished - Feb 2024

Keywords

  • CuO@Ag heterostructure
  • Label-free detection
  • SERS bioprobe
  • Tumor subtypes identification
  • Ultrahigh sensitivity

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • General Materials Science
  • Pharmaceutical Science

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