Recent ultrasound advancements for the manipulation of nanobiomaterials and nanoformulations for drug delivery

Sze Shin Low, Chang Nong Lim, Maxine Yew, Wai Siong Chai, Liang Ee Low, Sivakumar Manickam, Beng Ti Tey, Pau Loke Show

Research output: Journal PublicationReview articlepeer-review

45 Citations (Scopus)


Recent advances in ultrasound (US) have shown its great potential in biomedical applications as diagnostic and therapeutic tools. The coupling of ultrasound-assisted drug delivery systems with nanobiomaterials possessing tailor-made functions has been shown to remove the limitations of conventional drug delivery systems. The low-frequency ultrasound has significantly enhanced the targeted drug delivery effect and efficacy, reducing limitations posed by conventional treatments such as a limited therapeutic window. The acoustic cavitation effect induced by the ultrasound-mediated microbubbles (MBs) has been reported to replace drugs in certain acute diseases like ischemic stroke. This review briefly discusses the ultrasound principles, with particular attention to the recent advancements in drug delivery applications. Furthermore, ultrasound-assisted drug delivery coupled with nanobiomaterials to treat different diseases (cancer, neurodegenerative disease, diabetes, thrombosis and COVID-19) is discussed. Finally, this review covers the future perspectives and challenges on the applications of ultrasound-mediated nanobiomaterials.

Original languageEnglish
Article number105805
JournalUltrasonics Sonochemistry
Publication statusPublished - Dec 2021
Externally publishedYes


  • COVID-19
  • Disease
  • Drug delivery
  • Nanobiomaterial
  • Ultrasound

ASJC Scopus subject areas

  • Environmental Chemistry
  • Chemical Engineering (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Acoustics and Ultrasonics
  • Organic Chemistry
  • Inorganic Chemistry


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