Recent progress in nanomaterials modified electrochemical biosensors for the detection of microRNA

Sze Shin Low, Daizong Ji, Wai Siong Chai, Jingjing Liu, Kuan Shiong Khoo, Sadegh Salmanpour, Fatemeh Karimi, Balakrishnan Deepanraj, Pau Loke Show

Research output: Journal PublicationReview articlepeer-review

63 Citations (Scopus)


MicroRNAs (miRNAs) are important non-coding, single-stranded RNAs possessing cru-cial regulating roles in human body. Therefore, miRNAs have received extensive attention from various disciplines as the aberrant expression of miRNAs are tightly related to different types of diseases. Furthermore, the exceptional stability of miRNAs has presented them as biomarker with high specificity and sensitivity. However, small size, high sequence similarity, low abundance of miRNAs impose difficulty in their detection. Hence, it is of utmost importance to develop accurate and sensitive method for miRNA biosensing. Electrochemical biosensors have been demonstrated as promising solution for miRNA detection as they are highly sensitive, facile, and low-cost with ease of miniaturization. The incorporation of nanomaterials to electrochemical biosensor offers excellent prospects for converting biological recognition events to electronic signal for the development of biosensing platform with desired sensing properties due to their unique properties. This review intro-duces the signal amplification strategies employed in miRNA electrochemical biosensor and presents the feasibility of different strategies. The recent advances in nanomaterial-based electrochemical biosensor for the detection of miRNA were also discussed and summarized based on different types of miRNAs, opening new approaches in biological analysis and early disease diagnosis. Lastly, the challenges and future prospects are discussed.

Original languageEnglish
Article number1409
Issue number11
Publication statusPublished - Nov 2021


  • Electrochemical biosensor
  • MicroRNA
  • Nanomaterial
  • Signal amplification strategy

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Mechanical Engineering
  • Electrical and Electronic Engineering


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