Recent advances in scaffolding from natural-based polymers for volumetric muscle injury

Tamrin Nuge, Ziqian Liu, Xiaoling Liu, Bee Chin Ang, Andri Andriyana, Hendrik Simon Cornelis Metselaar, Md Enamul Hoque

Research output: Journal PublicationReview articlepeer-review

15 Citations (Scopus)


Volumetric Muscle Loss (VML) is associated with muscle loss function and often untreated and considered part of the natural sequelae of trauma. Various types of biomaterials with different physical and properties have been developed to treat VML. However, much work remains yet to be done before the scaffolds can pass from the bench to the bedside. The present review aims to provide a comprehensive summary of the latest developments in the construction and application of natural polymers-based tissue scaffolding for volumetric muscle injury. Here, the tissue engineering approaches for treating volumetric muscle loss injury are highlighted and recent advances in cell-based therapies using various sources of stem cells are elaborated in detail. An overview of different strategies of tissue scaffolding and their efficacy on skeletal muscle cells regeneration and migration are presented. Furthermore, the present paper discusses a wide range of natural polymers with a special focus on proteins and polysaccharides that are major components of the extracellular matrices. The natural polymers are biologically active and excellently promote cell adhesion and growth. These bio-characteristics justify natural polymers as one of the most attractive options for developing scaffolds for muscle cell regeneration.

Original languageEnglish
Article number699
Issue number3
Publication statusPublished - 1 Feb 2021


  • Acellular
  • Electrospun
  • Hydrogels
  • Stem cells
  • Tissue engineering
  • Volumetric Muscle Loss (VML)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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