Qualified predictions for microarray and proteomics pattern diagnostics with confidence machines

Tony Bellotti, Zhiyuan Luo, Alex Gammerman, Frederick W. Van Delft, Vaskar Saha

Research output: Journal PublicationArticlepeer-review

39 Citations (Scopus)


We focus on the problem of prediction with confidence and describe a recently developed learning algorithm called transductive confidence machine for making qualified region predictions. Its main advantage, in comparison with other classifiers, is that it is well-calibrated, with number of prediction errors strictly controlled by a given predefined confidence level. We apply the transductive confidence machine to the problems of acute leukaemia and ovarian cancer prediction using microarray and proteomics pattern diagnostics, respectively. We demonstrate that the algorithm performs well, yielding well-calibrated and informative predictions whilst maintaining a high level of accuracy.

Original languageEnglish
Pages (from-to)247-258
Number of pages12
JournalInternational Journal of Neural Systems
Issue number4
Publication statusPublished - Aug 2005
Externally publishedYes


  • Classification
  • Confidence machine
  • Machine learning
  • Microarray
  • Proteomics

ASJC Scopus subject areas

  • Computer Networks and Communications


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