Nuclear cataract classification in anterior segment OCT based on clinical global–local features

Xiaoqing Zhang, Zunjie Xiao, Xiao Wu, Yu Chen, Risa Higashita, Wan Chen, Jin Yuan, Jiang Liu

Research output: Journal PublicationArticlepeer-review


Nuclear cataract (NC) is a priority ocular disease of blindness and vision impairment globally. Early intervention and cataract surgery can improve the vision and life quality of NC patients. Anterior segment coherence tomography (AS-OCT) imaging is a non-invasive way to capture the NC opacity objectively and quantitatively. Recent clinical research has shown that there exists a strong opacity correlation relationship between NC severity levels and the mean density on AS-OCT images. In this paper, we present an effective NC classification framework on AS-OCT images, based on feature extraction and feature importance analysis. Motivated by previous clinical knowledge, our method extracts the clinical global–local features, and then applies Pearson’s correlation coefficient and recursive feature elimination methods to analyze the feature importance. Finally, an ensemble logistic regression is employed to distinguish NC, which considers different optimization methods’ characteristics. A dataset with 11,442 AS-OCT images is collected to evaluate the method. The results show that the proposed method achieves 86.96% accuracy and 88.70% macro-sensitivity, respectively. The performance comparison analysis also demonstrates that the global–local feature extraction method improves about 2% accuracy than the single region-based feature extraction method.

Original languageEnglish
Pages (from-to)1479-1493
Number of pages15
JournalComplex and Intelligent Systems
Issue number2
Publication statusPublished - Apr 2023
Externally publishedYes


  • AS-OCT image
  • Classification
  • Global–local features
  • Machine learning
  • Nuclear cataract

ASJC Scopus subject areas

  • Information Systems
  • Engineering (miscellaneous)
  • Computational Mathematics
  • Artificial Intelligence


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