Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity

C. J. Woolf, B. Safieh-Garabedian, Q. P. Ma, P. Crilly, J. Winter

Research output: Journal PublicationArticlepeer-review

609 Citations (Scopus)


Experimental inflammation produced by an intraplantar injection of complete Freund's adjuvant results in local sensory hypersensitivity and up-regulates the neuropeptides substance P and calcitonin gene related peptide in the primary sensory neurons innervating the inflamed tissue. The inflammation also elevates nerve growth factor levels in the skin. Systemic administration of anti-NGF neutralizing antibodies prevent the behavioral sensitivity, the up-regulation of neuropeptides and the inflammation-induced expression of the immediate early gene c-fos in dorsal horn neurons, without modifying swelling and erythema. Elevation of the neurotrophin NGF in the periphery is a major contributor, therefore, of inflammatory pain.

Original languageEnglish
Pages (from-to)327-331
Number of pages5
Issue number2
Publication statusPublished - Sept 1994
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience


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