Multigram Synthesis of Trioxanes Enabled by a Supercritical CO₂Integrated Flow Process

Keyphrases

• 1,2,4-trioxanes 66%
• Anticancer Treatment 33%
• Antimalarial Activity 33%
• Antimalarial Drugs 33%
• Aromatization 33%
• Artemisinin 33%
• Continuous Approach 33%
• Continuous Processing 33%
• Excellent Yields 33%
• Flow Condition 33%
• Flow Process 100%
• Gram-scale 33%
• High Atom Utilization 33%
• High Pressure 33%
• Hydroperoxides 33%
• Low Viscosity 33%
• Molecular Oxygen 33%
• Multigram Synthesis 100%
• Multigrams 33%
• Oxidizable 33%
• Para-substituted Phenols 33%
• Pharmaceutical Manufacturing 33%
• Photo-generated 33%
• Photobioreactor 33%
• Photosynthesis 33%
• Reaction Time 33%
• Reactor 33%
• Sapphire 33%
• Short Reaction Time 33%
• Singlet Oxygen 33%
• Solid Acid Catalyst 33%
• Solid Oxidizer 33%
• Supercritical CO2 (SCO2) 33%
• Synthetic Approaches 33%
• Synthetic Organic Chemistry 33%
• Treatment Drugs 33%
• Trioxane 100%
• Useful Products 33%
• Value-added Compounds 33%

Chemistry

• Acid Catalyst 20%
• Antimalarial 20%
• Antimalarial Agent 20%
• Carbon Dioxide 40%
• Dioxygen 20%
• Hydroperoxide 20%
• Organic Chemistry 20%
• Phenol 20%
• Sapphire 20%
• Trioxane 100%