MiRTarBase 2020: Updates to the experimentally validated microRNA-target interaction database

Hsi Yuan Huang, Yang Chi Dung Lin, Jing Li, Kai Yao Huang, Sirjana Shrestha, Hsiao Chin Hong, Yun Tang, Yi Gang Chen, Chen Nan Jin, Yuan Yu, Jia Tong Xu, Yue Ming Li, Xiao Xuan Cai, Zhen Yu Zhou, Xiao Hang Chen, Yuan Yuan Pei, Liang Hu, Jin Jiang Su, Shi Dong Cui, Fei WangYue Yang Xie, Si Yuan Ding, Meng Fan Luo, Chih Hung Chou, Nai Wen Chang, Kai Wen Chen, Yu Hsiang Cheng, Xin Hong Wan, Wen Lian Hsu, Tzong Yi Lee, Feng Xiang Wei, Hsien Da Huang

Research output: Journal PublicationArticlepeer-review

549 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs (typically consisting of 18-25 nucleotides) that negatively control expression of target genes at the post-transcriptional level. Owing to the biological significance of miRNAs, miRTarBase was developed to provide comprehensive information on experimentally validated miRNA-target interactions (MTIs). To date, the database has accumulated >13,404 validated MTIs from 11,021 articles from manual curations. In this update, a text-mining system was incorporated to enhance the recognition of MTI-related articles by adopting a scoring system. In addition, a variety of biological databases were integrated to provide information on the regulatory network of miRNAs and its expression in blood. Not only targets of miRNAs but also regulators of miRNAs are provided to users for investigating the up-and downstream regulations of miRNAs. Moreover, the number of MTIs with high-throughput experimental evidence increased remarkably (validated by CLIP-seq technology). In conclusion, these improvements promote the miRTarBase as one of the most comprehensively annotated and experimentally validated miRNA-target interaction databases. The updated version of miRTarBase is now available at http://miRTarBase.cuhk.edu.cn/.

Original languageEnglish
Pages (from-to)D148-D154
JournalNucleic Acids Research
Volume48
Issue numberD1
DOIs
Publication statusPublished - 1 Jan 2020
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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