Integrated approach to crystallization process design for fine chemicals and pharmaceuticals

Christianto Wibowo, Ketan D. Samant, Lionel O'Young

Research output: Journal PublicationArticlepeer-review

1 Citation (Scopus)

Abstract

Designing a crystallization process that can recover the right product with a reasonably high yield and sufficiently high purity is often a key task in ensuring overall process feasibility in the fine chemical and pharmaceutical industry. An integrated approach for crystallization process design which combines synthesis with modeling and experimental activities is presented. By first modeling the thermodynamic behavior of the system, feasible operating regions and the need for further experimental verification can be identified. Kinetics and mass transfer effects are considered next. Modeling of phase behavior and relevant downstream operations helps to design experiments and organize the results in a meaningful way, and more importantly, points to the right direction as to what should be done next, thereby minimizing the required time, effort, and cost for developing the process.

Original languageEnglish
Pages (from-to)749-754
Number of pages6
JournalComputer Aided Chemical Engineering
Volume21
Issue numberC
DOIs
Publication statusPublished - 2006
Externally publishedYes

Keywords

  • Crystallization
  • Process synthesis
  • Solid-liquid equilibrium

ASJC Scopus subject areas

  • Chemical Engineering (all)
  • Computer Science Applications

Fingerprint

Dive into the research topics of 'Integrated approach to crystallization process design for fine chemicals and pharmaceuticals'. Together they form a unique fingerprint.

Cite this