GSH levels serve as a biological redox switch regulating sulforaphane-induced cell fate in human lens cells

Keyphrases

• Activating Transcription Factor 6 (ATF6) 7%
• Activity Ratio 7%
• Antioxidant 7%
• Autophagy 15%
• Cell Damage 7%
• Cell Death 23%
• Cell Fate 100%
• Cellular Events 7%
• Conjugation 7%
• Cytotoxicity 7%
• DNA Damage 23%
• Endoplasmic Reticulum Stress (ER stress) 15%
• Epithelial Cell Line 7%
• Epithelium 7%
• FHL124 15%
• Gene Level 7%
• Glutathione Reductase 23%
• GSH Level 100%
• Health Condition 7%
• Human Lens Cells 100%
• Human Lens Epithelial Cells 7%
• Immunoblotting 7%
• Immunofluorescence 7%
• Induced Cell Death 7%
• Lens Cell 30%
• Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) 7%
• Mechanistic Understanding 7%
• Microscopic Observation 7%
• Mitochondrial DNA 7%
• Mitochondrial Dysfunction 15%
• Mitochondrial Membrane Potential 7%
• Mitochondrial Network 7%
• Multiplex Real-time PCR 7%
• N-acetylcysteine 15%
• Network Damage 7%
• Oxidative Stress 7%
• Oxidized Glutathione 7%
• Phytochemical Constituents 7%
• Posterior Capsule Opacification 15%
• Protein Level 15%
• Reactive Oxygen Species Scavenger 7%
• Reactive Oxygen Stress 7%
• Redox Switch 100%
• Reduced Glutathione 15%
• Reductase Activity 23%
• Reporter Assay 7%
• Stress Damage 7%
• Sulforaphane 100%
• Sulforaphane Metabolites 7%
• Therapeutic Use 7%
• Viability Assay 7%

Immunology and Microbiology

• Activating Transcription Factor 6 25%
• Autophagy 50%
• Cell Damage 25%
• Cell Death 100%
• Cell Fate 100%
• Cytotoxicity 25%
• DNA Damage 75%
• Endoplasmic Reticulum Stress 50%
• Epithelial Cell Line 25%
• Experimental Model 25%
• Immunofluorescence 25%
• Liquid Chromatography Mass Spectrometry 25%
• Metabolite 25%
• Mitochondrial Membrane Potential 25%
• Oxidative Stress 25%
• Reverse Transcription Polymerase Chain Reaction 25%
• Tandem Mass Spectrometry 25%
• Western Blot 25%

Medicine and Dentistry

• Acetylcysteine 14%
• Activating Transcription Factor 6 7%
• Antioxidant 7%
• Autophagy 14%
• Cataract 14%
• Cell Damage 7%
• Cell Death 28%
• Cell Fate 100%
• Cytotoxicity 7%
• Disease 7%
• DNA Damage 21%
• Endoplasmic Reticulum Stress 14%
• Epithelial Cell Line 7%
• Glutathione 14%
• Glutathione Disulfide 7%
• Glutathione Reductase 21%
• Immunoblotting 7%
• Immunofluorescence 7%
• Liquid Chromatography-Mass Spectrometry 7%
• Metabolite 7%
• Mitochondrial Membrane Potential 7%
• Oxidative Stress 7%
• Phytochemical 7%
• Reactive Oxygen Species 14%
• Reverse Transcription Polymerase Chain Reaction 7%
• Sulforaphane 100%
• Tandem Mass Spectrometry 7%