Extending the range of diffusion times for regional measurement of the 3He ADC in human lungs

Chengbo Wang, G. Wilson Miller, Talissa A. Altes, Eduard E. De Lange, Gordon D. Cates, Jaime F. Mata, James R. Brookeman, John P. Mugler

Research output: Journal PublicationArticlepeer-review

13 Citations (Scopus)


A stimulated-echo-based technique was developed to measure the regional apparent diffusion coefficient (ADC) of hyperpolarized 3He during a single breathhold for diffusion times of 25 ms or greater. Compared to previous methods, a substantially shorter minimum diffusion time was achieved by decoupling diffusion sensitization from image acquisition. A hyperpolarized-gas phantom was used to validate the method, which was then tested in four healthy subjects in whom regional ADC maps were acquired with diffusion times of 50, 200, and 1500 ms and a tag wavelength of 5 or 10 mm. ADC values from healthy subjects were in good agreement with reported literature values and decreased with increasing diffusion time. Mean ADC values were 0.07, 0.03, and 0.015 cm2/s for diffusion times of 50, 200, and 1500 ms, respectively. ADC maps were generally homogeneous, with similar mean values when measured with the same parameters in different subjects.

Original languageEnglish
Pages (from-to)673-678
Number of pages6
JournalMagnetic Resonance in Medicine
Issue number3
Publication statusPublished - Mar 2008
Externally publishedYes


  • Diffusion MRI
  • Hyperpolarized helium
  • MRI of lung
  • Pulse sequence
  • Stimulated echo

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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