Dupuytren's disease risk factors

John M. Geoghegan, J. Forbes, D. I. Clark, C. Smith, R. Hubbard

Research output: Journal PublicationArticlepeer-review

97 Citations (Scopus)

Abstract

Dupuytren's is a common problem, but little is known about its aetiology. We have undertaken a large case-control study to assess and quantify the relative contributions of diabetes and epilepsy as risk factors for Dupuytren's in the community. Cases were patients with a diagnosis of Dupuytren's disease and, for each, two controls were individually matched by age, sex, and general practice. Our dataset included 821 cases and 1,642 controls. Five hundred and eighty-eight (72%) of the cases were men. The mean age at diagnosis was 62 (range 24-97) years. Diabetes was a significant risk factor for Dupuytren's disease (OR=1.75) and there was an increased risk for medicinally treated diabetes (metformin - R=3.56; sulphonylureas - OR=1.75) and particularly insulin controlled (OR=4.39) rather than diet-controlled diabetes. Epilepsy (OR=1.12) and anti-epileptic medications were not associated with Dupuytren's disease. Ascertainment bias in previous studies may explain the reported association with epilepsy.

Original languageEnglish
Pages (from-to)423-426
Number of pages4
JournalJournal of Hand Surgery
Volume29
Issue number5
DOIs
Publication statusPublished - Oct 2004
Externally publishedYes

Keywords

  • Case-control study
  • Diabetes
  • Dupuytren's disease
  • Epilepsy
  • General practice research database

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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