Continuous Protein Recovery with a Liquid-Solid Circulating Fluidized-Bed Ion Exchanger

Qingdao Lan, Amarjeet S. Bassi, Jing Xu Zhu, Argyrios Margaritis

Research output: Journal PublicationArticlepeer-review

55 Citations (Scopus)


A liquid-solid circulating fluidized-bed (LSCFB) ion-exchange system was developed for continuous protein recovery. It contains a downcomer for protein adsorption and a riser for protein desorption, with ion-exchange particles circulating continuously between the two columns. Effects of the operating conditions on the hydrodynamics and the continuous ion exchange of bovine serum albumin (BSA) in the system were investigated. Under typical operating conditions, up to 98% BSA was adsorbed in the down-comer (showing a very high efficiency of protein removal from the feed), and an overall protein recovery of up to 84% was obtained in the LSCFB system, indicating that the LSCFB system was a very promising strategy for the continuous recovery of proteins.

Original languageEnglish
Pages (from-to)252-261
Number of pages10
JournalAICHE Journal
Issue number2
Publication statusPublished - Feb 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Environmental Engineering
  • General Chemical Engineering


Dive into the research topics of 'Continuous Protein Recovery with a Liquid-Solid Circulating Fluidized-Bed Ion Exchanger'. Together they form a unique fingerprint.

Cite this