Characterization and optimization of the mechanical properties of electrospun gelatin nanofibrous scaffolds

Tamrin Nuge, Kim Yeow Tshai, Siew Shee Lim, Norshariza Nordin, Md Enamul Hoque

Research output: Journal PublicationArticlepeer-review

9 Citations (Scopus)

Abstract

Purpose: Electrospinning is a versatile technique for producing polymeric nanofibers by the application of electrostatic forces. The electrospinnability of polymeric solutions and the properties of electrospun nanofibers can be influenced and tuned by the process parameters. This paper aims to investigatethe influence of three key process parameters on the tensile strength of electrospun gelatin nanofibrous scaffold. Design/methodology/approach: The experiments were conducted with a custom-built electrospinning system. Design of experiments of the three operating variables, namely, gelatin concentration, applied potential and feed rate, with five levels were investigated. Optimization of the tensile strength of electrospun gelatin scaffold was achieved with the aid of response surface methodology. Findings: The resulting second-order mathematical models capable of demonstrating good correlation on the effects of the three identified process parameters with the experimental measured tensile strength, where the highest tensile strength was obtained on gelatin nanofibrous scaffold electrospun at 16per cent (w/v) gelatin concentration in acetic acid, 19 kV applied potential and 0.31 ml/h feed rate. Originality/value: The resulting second-order mathematical models capable of demonstrating good correlation on the effects of the three identified process parameters with the experimental measured tensile strength, where the highest tensile strength was obtained on gelatin nanofibrous scaffold electrospun at 16per cent (w/v) gelatin concentration in acetic acid, 19 kV applied potential and 0.31 ml/h feed rate.

Original languageEnglish
Pages (from-to)12-20
Number of pages9
JournalWorld Journal of Engineering
Volume17
Issue number1
DOIs
Publication statusPublished - 19 Feb 2020
Externally publishedYes

Keywords

  • Electrospinning
  • Mechanical properties
  • Nanofibers
  • Response surface methodology

ASJC Scopus subject areas

  • Civil and Structural Engineering
  • Geotechnical Engineering and Engineering Geology
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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