Application and Progress of Chemometrics in Voltammetric Biosensing

Jingjing Liu, Yifei Xu, Shikun Liu, Shixin Yu, Zhirun Yu, Sze Shin Low

Research output: Journal PublicationArticlepeer-review

26 Citations (Scopus)


The voltammetric electrochemical sensing method combined with biosensors and multi-sensor systems can quickly, accurately, and reliably analyze the concentration of the main analyte and the overall characteristics of complex samples. Simultaneously, the high-dimensional voltammogram contains the rich electrochemical features of the detected substances. Chemometric methods are important tools for mining valuable information from voltammetric data. Chemometrics can aid voltammetric biosensor calibration and multi-element detection in complex matrix conditions. This review introduces the voltammetric analysis techniques commonly used in the research of voltammet-ric biosensor and electronic tongues. Then, the research on optimizing voltammetric biosensor results using classical chemometrics is summarized. At the same time, the incorporation of machine learning and deep learning has brought new opportunities to further improve the detection performance of biosensors in complex samples. Finally, smartphones connected with miniaturized voltammetric biosensors and chemometric methods provide a high-quality portable analysis platform that shows great potential in point-of-care testing.

Original languageEnglish
Article number494
Issue number7
Publication statusPublished - Jul 2022


  • biosensing
  • chemometrics
  • point-of-care testing
  • smartphones
  • voltammetric methods

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biotechnology
  • Biomedical Engineering
  • Instrumentation
  • Engineering (miscellaneous)
  • Clinical Biochemistry


Dive into the research topics of 'Application and Progress of Chemometrics in Voltammetric Biosensing'. Together they form a unique fingerprint.

Cite this