Projects per year
Personal profile
Research Interests
1. Biomimetic Synthesis of Natural Products
1) Studies of the Biomimetic Total Synthesis of Providencin.
Key paper: Org. Lett. 2019, 21, 1243–1247.
The unique structure of furanocembranoid natural product providencin has provoked biosynthetic hypotheses, especially in respect of the formation of its cyclobutanol ring. One such hypothesis for the formation of providencin involves a photochemically-induced Norrish-Yang cyclisation in bipinnatin E. We used quantum chemical calculations to assess the feasibility and the stereochemical outcome of this proposed biosynthetic transformation.
2) Thermal and Photochemical Mechanisms for Cyclobutane Formation in Bielschowskysin Biosynthesis.
Key paper: Synlett, 2015, 26, 501-507
Bielschowskysin is a complex furanocembranoid natural product, exhibiting impressive antiplasmodial and anticancer activity. The structure and biological profile of bielschowskysin, coupled with its natural scarcity, have provoked a number of biosynthetic hypotheses. Quantum chemical calculations provide a means to assess the feasibility of postulated mechanisms in the construction of this unusual carbon skeleton. We use calculations to biosynthesis of bielschowskysin in nature.
2. Computational Studies for CO2 Reduction Reactions for Small Molecular Fuels
Fossil fuels (coal, oil and natural gas) are the main energy sources and the primary raw material sources for chemical industry. However, these are natural gifts are unrenewable energy resources. The society is facing challenging problems caused by over consumption of fossil fuels, i.e. decreased easily accessible fossil fuels and increased release of carbon dioxide (CO2), leading to serious environmental problems. We aim to contribute to solving this challenging, by developing technology to convert atmospheric CO2 into useful fuels, through a theoretical investigation and experiment combined approach.
3. Computational Studies of Novel Reaction Mechanisms
Mechanistic studies using quantum chemical calculations by working with experiment research groups.
1) Gold-Catalyzed Reactions:Eur.J.Org. Chem. 2017, 11, 1561-1565;
2) Copper-catalyzed Reactions:Green Chem. 2017, 19, 4509-4514;
3) DFT Study of Pericyclic Reactions for Natural Product Synthesis: Nature Communications, 2018, 9, 4040-4046;
Teaching
- Physical and Process Chemistry
- Engineering Principles 1
- Heat and Mass Transfer
- Interfacial Chemistry
- Analytical Measurement
- Academy Organic Chemistry
- An Introduction to Organic Molecules and their Reactivity
Person Types
- Staff
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Collaborations and top research areas from the last five years
Projects
- 5 Finished
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Platform Application for Innovation China
1/09/21 → 31/08/22
Project: Government Funded Projects › Vertical-Ningbo Municipal Government Funded Projects
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Development of Muc-001 as an innovative drug targeting tumor stem cells
1/11/20 → 31/10/23
Project: Government Funded Projects › Vertical-Ningbo Municipal Government Funded Projects
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Research and Development of Alternative Feeding Antibiotic Products from Herbs
30/09/19 → 31/07/22
Project: Government Funded Projects › Vertical-National Government Funded Projects
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Study on the Reaction Mechanism of Copper-catalyzed Carbon Dioxide Reduction to Small Molecule Fuel by Density Functional Theory (DFT) and the Design of New Catalytic System
1/10/16 → 30/09/18
Project: Government Funded Projects › Vertical-Ningbo Municipal Government Funded Projects
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Studies of the Biomimetic Total Synthesis of Providencin
National Natural Science Foundation of China (NSFC)
1/01/16 → 31/12/18
Project: Government Funded Projects › Vertical-National Government Funded Projects
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Alkoxy Substitution on Asymmetric Conjugated Molecule Enabling over 18% Efficiency in Ternary Organic Solar Cells by Reducing Nonradiative Voltage Loss
Xie, L., Lan, A., Gu, Q., Yang, S., Song, W., Ge, J., Zhou, R., Chen, Z., Zhang, J., Zhang, X., Yang, D., Tang, B., Wu, T. & Ge, Z., 13 Jan 2023, In: ACS Energy Letters. 8, 1, p. 361-371 11 p.Research output: Journal Publication › Article › peer-review
23 Citations (Scopus) -
Multideuteration of Nitroaromatics by Silver-Catalyzed Hydrogen-Isotope Exchange
Tang, J., Kong, J., Xu, H., Jiang, Z. J., She, Y., Bai, J., Tang, B., Chen, J., Gao, Z. & Gao, K., 3 Feb 2023, In: Journal of Organic Chemistry. 88, 3, p. 1560-1567 8 p.Research output: Journal Publication › Article › peer-review
1 Citation (Scopus) -
Potassium tert-butoxide promoted regioselective deuteration of pyridines
Li, Y., Zheng, C., Jiang, Z. J., Tang, J., Tang, B. & Gao, Z., 14 Feb 2022, In: Chemical Communications. 58, 21, p. 3497-3500 4 p.Research output: Journal Publication › Article › peer-review
7 Citations (Scopus) -
Rational tuning of intermolecular and intramolecular interactions enabling high-efficiency indoor organic photovoltaics
Xie, L., Zhang, J., Song, W., Ge, J., Li, D., Zhou, R., Zhang, J., Zhang, X., Yang, D., Tang, B., Wu, T. & Ge, Z., Aug 2022, In: Nano Energy. 99, 12 p., 107414.Research output: Journal Publication › Article › peer-review
12 Citations (Scopus) -
Regioselective Cycloaddition and Substitution Reaction of Tertiary Propargylic Alcohols and Heteroareneboronic Acids via Acid Catalysis
Bai, J. F., Tang, J., Gao, X., Jiang, Z. J., Tang, B., Chen, J. & Gao, Z., 1 Jul 2022, In: Organic Letters. 24, 25, p. 4507-4512 6 p.Research output: Journal Publication › Article › peer-review
3 Citations (Scopus)