The progressive tactile hyperalgesia induced by peripheral inflammation is nerve growth factor dependent

Qing Ping Ma, Clifford J. Woolf

Research output: Journal PublicationArticlepeer-review

70 Citations (Scopus)

Abstract

Experimental peripheral inflammation results in cutaneous mechanical hypersensitivity low intensity mechanical stimulation of inflamed skin induces a progressively incrementing hyperalgesia. We have now examined whether the elevation in nerve growth factor (NGF) induced by the inflammation contributes to this progressive hyperalgesia. An i.p. injection of anti-NGF antiserum (5μl g-1) 1h before induction of inflammation by intraplantar complete Freund's adjuvant (CFA) injection and 24 h after, both reduced the basal inflammatory hypersensitivity and significantly attenuated the progressive increase of spontaneous activity, touch-, pinch- and Aβ-afferent-evoked responses, and the progressive reduction of the mechanical threshold of biceps femoris/semitendinosus alpha motoneurones normally evoked by repeated (every 5 min) tactile stimulation of the inflamed hindpaw, in decerebrate-spinal rats. NGF contributes, therefore, to the progressive tactile hyperalgesia elicited by repeated touch stimulation of inflamed tissue.

Original languageEnglish
Pages (from-to)807-810
Number of pages4
JournalNeuroReport
Volume8
Issue number4
DOIs
Publication statusPublished - 1997
Externally publishedYes

Keywords

  • Allodynia
  • Hyperalgesia
  • Inflammation
  • NGF
  • Pain
  • Sensory neurone
  • Spinal cord

ASJC Scopus subject areas

  • General Neuroscience

Fingerprint

Dive into the research topics of 'The progressive tactile hyperalgesia induced by peripheral inflammation is nerve growth factor dependent'. Together they form a unique fingerprint.

Cite this