The acute impact of a hematopoietic allograft on lung function and inflammation: A prospective observational study

Alexandra Enocson, Richard Hubbard, Tricia McKeever, Nigel Russell, Jennifer Byrne, Emma Das-Gupta, Lynne Watson, Andrew W. Fogarty

Research output: Journal PublicationArticlepeer-review

3 Citations (Scopus)

Abstract

Background: No studies have investigated the immediate impact of receiving an allogeneic hematopoietic stem cell transplant (HSCT) on pulmonary inflammation or lung function.Methods: Using a prospective study design, we quantified the changes in these outcome measures in eligible adult individuals in the first six months after receiving an allogeneic hematopoietic stem cell transplant.Results: Between January 2007 and December 2008, 72 patients were eligible to participate in the cohort, and of these 68 (94%) were included in the study. Compared to baseline, pulmonary inflammation as measured by exhaled nitric oxide increased after receiving a HSCT with the largest increment seen at three months (+6.0ppb, 95%CI: +0.4 to +11.5), and this was sustained at six months. Percent predicted forced expiratory volume in one second decreased over the same period, with the largest decrease observed at six weeks (-5.9%, 95% CI: -8.9 to -2.9), and this was also sustained over a six month period. Similar associations were observed for FVC. A larger increase in exhaled nitric oxide from baseline at six weeks and three months may be associated with decreased mortality (p=0.06, p=0.04 respectively).Conclusion: Our data demonstrate that recipients of an allogeneic HSCT experience an increase in biomarkers of pulmonary inflammation and a decrease in lung function in the first six months after the procedure. If independently validated in other study populations, these observations could have potential as a prognostic biomarker for this patient group.

Original languageEnglish
Article number2
JournalBMC Pulmonary Medicine
Volume13
Issue number1
DOIs
Publication statusPublished - 11 Jan 2013
Externally publishedYes

Keywords

  • Haematopoietic transplant
  • Inflammation
  • Lung function

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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