TY - GEN
T1 - Temporal and antigenic analysis of dengue virus serotype 1 genome polyprotein sequences
AU - Rajapakse, Menaka
AU - Veeramani, Anitha
AU - Gopalakrishnan, Kavitha
AU - Ananthanarayan, Sivagami
AU - Khan, Asif M.
AU - Srinivasan, K. N.
AU - August, J. Thomas
AU - Brusic, Vladimir
PY - 2006
Y1 - 2006
N2 - Dengue virus poses a significant health threat. The new emerging strains continue to cause annual epidemics. In this paper, we report results of an analysis of dengue virus serotype 1 (DV1) genome polyprotein sequences in the context of time and geographical distribution. We studied the clustering of 60 DV1 genome polyprotein sequences of different geographical distributions, reported in the past 30 years, to identify geographic and temporal patterns of genetic and antigenic variation. Our analysis showed distinct clustering of sequences into two main geographical regions: i) Western and South Pacific and South-East Asian region (with three distinct sub-clusters) and ii) South American region. The results provide evidence suggesting temporal changes of the isolated strains. In addition, our analysis indicated that potential T-cell epitope hotspots within DV1 are shifting with time and recurrent epidemics, resulting in disappearing of some hotspots and emerging of new hotspots.
AB - Dengue virus poses a significant health threat. The new emerging strains continue to cause annual epidemics. In this paper, we report results of an analysis of dengue virus serotype 1 (DV1) genome polyprotein sequences in the context of time and geographical distribution. We studied the clustering of 60 DV1 genome polyprotein sequences of different geographical distributions, reported in the past 30 years, to identify geographic and temporal patterns of genetic and antigenic variation. Our analysis showed distinct clustering of sequences into two main geographical regions: i) Western and South Pacific and South-East Asian region (with three distinct sub-clusters) and ii) South American region. The results provide evidence suggesting temporal changes of the isolated strains. In addition, our analysis indicated that potential T-cell epitope hotspots within DV1 are shifting with time and recurrent epidemics, resulting in disappearing of some hotspots and emerging of new hotspots.
KW - Dengue virus
KW - Geographic
KW - Human leukocyte antigen
KW - Serotype
KW - Supertype
KW - T-cell epitope hotspots
KW - Temporal
UR - http://www.scopus.com/inward/record.url?scp=46249108545&partnerID=8YFLogxK
U2 - 10.1109/ICBPE.2006.348604
DO - 10.1109/ICBPE.2006.348604
M3 - Conference contribution
AN - SCOPUS:46249108545
SN - 8190426249
SN - 9788190426244
T3 - ICBPE 2006 - Proceedings of the 2006 International Conference on Biomedical and Pharmaceutical Engineering
SP - 301
EP - 306
BT - ICBPE 2006 - Proceedings of the 2006 International Conference on Biomedical and Pharmaceutical Engineering
T2 - ICBPE 2006 - 2006 International Conference on Biomedical and Pharmaceutical Engineering
Y2 - 11 December 2006 through 14 December 2006
ER -
