Streptomyces monashensis sp. nov., a novel mangrove soil actinobacterium from East Malaysia with antioxidative potential

Jodi Woan Fei Law; Hooi Leng Ser; Nurul Syakima Ab Mutalib; Surasak Saokaew; Acharaporn Duangjai; Tahir Mehmood Khan; Kok Gan Chan; Bey Hing Goh; Learn Han Lee

doi:10.1038/s41598-019-39592-6

Streptomyces monashensis sp. nov., a novel mangrove soil actinobacterium from East Malaysia with antioxidative potential

Jodi Woan Fei Law, Hooi Leng Ser, Nurul Syakima Ab Mutalib, Surasak Saokaew, Acharaporn Duangjai, Tahir Mehmood Khan, Kok Gan Chan, Bey Hing Goh, Learn Han Lee

Research output: Journal Publication › Article › peer-review

55 Citations (Scopus)

Abstract

A new Streptomyces species discovered from Sarawak mangrove soil is described, with the proposed name – Streptomyces monashensis sp. nov. (strain MUSC 1J^T). Taxonomy status of MUSC 1J^T was determined via polyphasic approach. Phylogenetic and chemotaxonomic properties of strain MUSC 1J^T were in accordance with those known for genus Streptomyces. Based on phylogenetic analyses, the strains closely related to MUSC 1J^T were Streptomyces corchorusii DSM 40340^T (98.7%), Streptomyces olivaceoviridis NBRC 13066^T (98.7%), Streptomyces canarius NBRC 13431^T (98.6%) and Streptomyces coacervatus AS-0823^T (98.4%). Outcomes of DNA–DNA relatedness between strain MUSC 1J^T and its closely related type strains covered from 19.7 ± 2.8% to 49.1 ± 4.3%. Strain MUSC 1J^T has genome size of 10,254,857 bp with DNA G + C content of 71 mol%. MUSC 1J^T extract exhibited strong antioxidative activity up to 83.80 ± 4.80% in the SOD assay, with significant cytotoxic effect against colon cancer cell lines HCT-116 and SW480. Streptomyces monashensis MUSC 1J^T (=DSM 103626^T = MCCC 1K03221^T) could potentially be a producer of novel bioactive metabolites; hence discovery of this new species may be highly significant to the biopharmaceutical industry as it could lead to development of new and useful chemo-preventive drugs.

Original language	English
Article number	3056
Journal	Scientific Reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41598-019-39592-6
Publication status	Published - 1 Dec 2019
Externally published	Yes

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@article{2912ddb805d24e3b806a6f9bf07a12f7,

title = "Streptomyces monashensis sp. nov., a novel mangrove soil actinobacterium from East Malaysia with antioxidative potential",

abstract = "A new Streptomyces species discovered from Sarawak mangrove soil is described, with the proposed name – Streptomyces monashensis sp. nov. (strain MUSC 1JT). Taxonomy status of MUSC 1JT was determined via polyphasic approach. Phylogenetic and chemotaxonomic properties of strain MUSC 1JT were in accordance with those known for genus Streptomyces. Based on phylogenetic analyses, the strains closely related to MUSC 1JT were Streptomyces corchorusii DSM 40340T (98.7%), Streptomyces olivaceoviridis NBRC 13066T (98.7%), Streptomyces canarius NBRC 13431T (98.6%) and Streptomyces coacervatus AS-0823T (98.4%). Outcomes of DNA–DNA relatedness between strain MUSC 1JT and its closely related type strains covered from 19.7 ± 2.8% to 49.1 ± 4.3%. Strain MUSC 1JT has genome size of 10,254,857 bp with DNA G + C content of 71 mol%. MUSC 1JT extract exhibited strong antioxidative activity up to 83.80 ± 4.80% in the SOD assay, with significant cytotoxic effect against colon cancer cell lines HCT-116 and SW480. Streptomyces monashensis MUSC 1JT (=DSM 103626T = MCCC 1K03221T) could potentially be a producer of novel bioactive metabolites; hence discovery of this new species may be highly significant to the biopharmaceutical industry as it could lead to development of new and useful chemo-preventive drugs.",

author = "Law, {Jodi Woan Fei} and Ser, {Hooi Leng} and {Ab Mutalib}, {Nurul Syakima} and Surasak Saokaew and Acharaporn Duangjai and Khan, {Tahir Mehmood} and Chan, {Kok Gan} and Goh, {Bey Hing} and Lee, {Learn Han}",

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doi = "10.1038/s41598-019-39592-6",

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AU - Law, Jodi Woan Fei

AU - Ser, Hooi Leng

AU - Ab Mutalib, Nurul Syakima

AU - Saokaew, Surasak

AU - Duangjai, Acharaporn

AU - Khan, Tahir Mehmood

AU - Chan, Kok Gan

AU - Goh, Bey Hing

AU - Lee, Learn Han

PY - 2019/12/1

Y1 - 2019/12/1

N2 - A new Streptomyces species discovered from Sarawak mangrove soil is described, with the proposed name – Streptomyces monashensis sp. nov. (strain MUSC 1JT). Taxonomy status of MUSC 1JT was determined via polyphasic approach. Phylogenetic and chemotaxonomic properties of strain MUSC 1JT were in accordance with those known for genus Streptomyces. Based on phylogenetic analyses, the strains closely related to MUSC 1JT were Streptomyces corchorusii DSM 40340T (98.7%), Streptomyces olivaceoviridis NBRC 13066T (98.7%), Streptomyces canarius NBRC 13431T (98.6%) and Streptomyces coacervatus AS-0823T (98.4%). Outcomes of DNA–DNA relatedness between strain MUSC 1JT and its closely related type strains covered from 19.7 ± 2.8% to 49.1 ± 4.3%. Strain MUSC 1JT has genome size of 10,254,857 bp with DNA G + C content of 71 mol%. MUSC 1JT extract exhibited strong antioxidative activity up to 83.80 ± 4.80% in the SOD assay, with significant cytotoxic effect against colon cancer cell lines HCT-116 and SW480. Streptomyces monashensis MUSC 1JT (=DSM 103626T = MCCC 1K03221T) could potentially be a producer of novel bioactive metabolites; hence discovery of this new species may be highly significant to the biopharmaceutical industry as it could lead to development of new and useful chemo-preventive drugs.

AB - A new Streptomyces species discovered from Sarawak mangrove soil is described, with the proposed name – Streptomyces monashensis sp. nov. (strain MUSC 1JT). Taxonomy status of MUSC 1JT was determined via polyphasic approach. Phylogenetic and chemotaxonomic properties of strain MUSC 1JT were in accordance with those known for genus Streptomyces. Based on phylogenetic analyses, the strains closely related to MUSC 1JT were Streptomyces corchorusii DSM 40340T (98.7%), Streptomyces olivaceoviridis NBRC 13066T (98.7%), Streptomyces canarius NBRC 13431T (98.6%) and Streptomyces coacervatus AS-0823T (98.4%). Outcomes of DNA–DNA relatedness between strain MUSC 1JT and its closely related type strains covered from 19.7 ± 2.8% to 49.1 ± 4.3%. Strain MUSC 1JT has genome size of 10,254,857 bp with DNA G + C content of 71 mol%. MUSC 1JT extract exhibited strong antioxidative activity up to 83.80 ± 4.80% in the SOD assay, with significant cytotoxic effect against colon cancer cell lines HCT-116 and SW480. Streptomyces monashensis MUSC 1JT (=DSM 103626T = MCCC 1K03221T) could potentially be a producer of novel bioactive metabolites; hence discovery of this new species may be highly significant to the biopharmaceutical industry as it could lead to development of new and useful chemo-preventive drugs.

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VL - 9

JO - Scientific Reports

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IS - 1

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ER -

Streptomyces monashensis sp. nov., a novel mangrove soil actinobacterium from East Malaysia with antioxidative potential

Abstract

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