Simultaneous quantification of acetaminophen and tryptophan using a composite graphene foam/Zr-MOF film modified electrode

Justin Claude Kemmegne-Mbouguen; Firmin Parfait Tchoumi; Edwige Mouafo-Tchinda; Henrietta W. Langmi; Sonwabo E. Bambalaza; Nicholas M. Musyoka; Chrispin Kowenje; Robert Mokaya

doi:10.1039/d0nj02374d

Simultaneous quantification of acetaminophen and tryptophan using a composite graphene foam/Zr-MOF film modified electrode

Justin Claude Kemmegne-Mbouguen, Firmin Parfait Tchoumi, Edwige Mouafo-Tchinda, Henrietta W. Langmi, Sonwabo E. Bambalaza, Nicholas M. Musyoka, Chrispin Kowenje, Robert Mokaya

Research output: Journal Publication › Article › peer-review

9 Citations (Scopus)

Abstract

A graphene foam/zirconium-based metal-organic framework composite (GF/UiO-66) was synthesised and then employed to modify glassy carbon electrodes (GCE). These modified electrodes were successfully used for the simultaneous detection and determination of acetaminophen (AC) and tryptophan (TRYP). The combination of GF and UiO-66 endowed the electrodes with a large surface area, good biological compatibility and stability as well as high selectivity and sensitivity. The linear calibration plots for AC and TRYP were obtained over the range of 0.5-200 μM (R2 = 0.999) and 0.5-113 μM (R2 = 0.999) with detection limits of 0.07 μM and 0.06 μM, respectively. The modified electrodes were successfully applied for the determination of AC and TRYP in a pharmaceutical preparation and urine, respectively.

Original language	English
Pages (from-to)	13108-13117
Number of pages	10
Journal	New Journal of Chemistry
Volume	44
Issue number	30
DOIs	https://doi.org/10.1039/d0nj02374d
Publication status	Published - 14 Aug 2020
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Materials Chemistry

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10.1039/d0nj02374d

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title = "Simultaneous quantification of acetaminophen and tryptophan using a composite graphene foam/Zr-MOF film modified electrode",

abstract = "A graphene foam/zirconium-based metal-organic framework composite (GF/UiO-66) was synthesised and then employed to modify glassy carbon electrodes (GCE). These modified electrodes were successfully used for the simultaneous detection and determination of acetaminophen (AC) and tryptophan (TRYP). The combination of GF and UiO-66 endowed the electrodes with a large surface area, good biological compatibility and stability as well as high selectivity and sensitivity. The linear calibration plots for AC and TRYP were obtained over the range of 0.5-200 μM (R2 = 0.999) and 0.5-113 μM (R2 = 0.999) with detection limits of 0.07 μM and 0.06 μM, respectively. The modified electrodes were successfully applied for the determination of AC and TRYP in a pharmaceutical preparation and urine, respectively.",

author = "Kemmegne-Mbouguen, {Justin Claude} and Tchoumi, {Firmin Parfait} and Edwige Mouafo-Tchinda and Langmi, {Henrietta W.} and Bambalaza, {Sonwabo E.} and Musyoka, {Nicholas M.} and Chrispin Kowenje and Robert Mokaya",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.",

year = "2020",

month = aug,

day = "14",

doi = "10.1039/d0nj02374d",

language = "English",

volume = "44",

pages = "13108--13117",

journal = "New Journal of Chemistry",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Simultaneous quantification of acetaminophen and tryptophan using a composite graphene foam/Zr-MOF film modified electrode

AU - Kemmegne-Mbouguen, Justin Claude

AU - Tchoumi, Firmin Parfait

AU - Mouafo-Tchinda, Edwige

AU - Langmi, Henrietta W.

AU - Bambalaza, Sonwabo E.

AU - Musyoka, Nicholas M.

AU - Kowenje, Chrispin

AU - Mokaya, Robert

PY - 2020/8/14

Y1 - 2020/8/14

N2 - A graphene foam/zirconium-based metal-organic framework composite (GF/UiO-66) was synthesised and then employed to modify glassy carbon electrodes (GCE). These modified electrodes were successfully used for the simultaneous detection and determination of acetaminophen (AC) and tryptophan (TRYP). The combination of GF and UiO-66 endowed the electrodes with a large surface area, good biological compatibility and stability as well as high selectivity and sensitivity. The linear calibration plots for AC and TRYP were obtained over the range of 0.5-200 μM (R2 = 0.999) and 0.5-113 μM (R2 = 0.999) with detection limits of 0.07 μM and 0.06 μM, respectively. The modified electrodes were successfully applied for the determination of AC and TRYP in a pharmaceutical preparation and urine, respectively.

AB - A graphene foam/zirconium-based metal-organic framework composite (GF/UiO-66) was synthesised and then employed to modify glassy carbon electrodes (GCE). These modified electrodes were successfully used for the simultaneous detection and determination of acetaminophen (AC) and tryptophan (TRYP). The combination of GF and UiO-66 endowed the electrodes with a large surface area, good biological compatibility and stability as well as high selectivity and sensitivity. The linear calibration plots for AC and TRYP were obtained over the range of 0.5-200 μM (R2 = 0.999) and 0.5-113 μM (R2 = 0.999) with detection limits of 0.07 μM and 0.06 μM, respectively. The modified electrodes were successfully applied for the determination of AC and TRYP in a pharmaceutical preparation and urine, respectively.

UR - http://www.scopus.com/inward/record.url?scp=85089577249&partnerID=8YFLogxK

U2 - 10.1039/d0nj02374d

DO - 10.1039/d0nj02374d

M3 - Article

AN - SCOPUS:85089577249

SN - 1144-0546

VL - 44

SP - 13108

EP - 13117

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 30

ER -

Simultaneous quantification of acetaminophen and tryptophan using a composite graphene foam/Zr-MOF film modified electrode

Abstract

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