TY - JOUR
T1 - Relationship of hard segment concentration in polyurethane-urea elastomers with mechanical, thermal and drug release properties
AU - Shoaib, Muhammad
AU - Bahadur, Ali
AU - Iqbal, Shahid
AU - Rahman, Muhammad Saif Ur
AU - Ahmed, Shakeel
AU - Shabir, Ghulam
AU - Javaid, Muhammad Asif
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - The main aim of this research was to study the effects of size and concentration of the hard segments on thermal stability, solvent resistance, hardness and drug delivery applications in polyurethane-urea (PUU) elastomers. Four diamines having different aliphatic chains, were synthesized and used as chain extenders (CE) to synthesize PUU. NCO/OH ratio was changed from 2-2.5 to study the effect of concentration of hard segments. Structure, morphology, thermal stability, hardness, solvent resistance, drug delivery and mechanical properties of polyurethane-urea elastomers were examined by means of fourier transform infrared spectroscopy (FTIR), wide-angle X-ray diffraction (WAXD), thermogravimetric analysis (TGA), shore durometer, UV/Vis spectrophotometer and universal testing machine (UTM) respectively.
AB - The main aim of this research was to study the effects of size and concentration of the hard segments on thermal stability, solvent resistance, hardness and drug delivery applications in polyurethane-urea (PUU) elastomers. Four diamines having different aliphatic chains, were synthesized and used as chain extenders (CE) to synthesize PUU. NCO/OH ratio was changed from 2-2.5 to study the effect of concentration of hard segments. Structure, morphology, thermal stability, hardness, solvent resistance, drug delivery and mechanical properties of polyurethane-urea elastomers were examined by means of fourier transform infrared spectroscopy (FTIR), wide-angle X-ray diffraction (WAXD), thermogravimetric analysis (TGA), shore durometer, UV/Vis spectrophotometer and universal testing machine (UTM) respectively.
KW - Chain extender
KW - Drug delivery
KW - Elastomers
KW - Polyurethane-urea
KW - Sustained release
KW - Thermally stable
UR - http://www.scopus.com/inward/record.url?scp=85006051867&partnerID=8YFLogxK
U2 - 10.1016/j.jddst.2016.12.003
DO - 10.1016/j.jddst.2016.12.003
M3 - Article
AN - SCOPUS:85006051867
SN - 1773-2247
VL - 37
SP - 88
EP - 96
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
ER -