Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr

Joseph S. Six; Theodore Hughes-Riley; David M.L. Lilburn; Alan C. Dorkes; Karl F. Stupic; Dominick E. Shaw; Peter G. Morris; Ian P. Hall; Galina E. Pavlovskaya; Thomas Meersmann

doi:10.1016/j.mri.2013.08.007

Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized ⁸³Kr

Joseph S. Six, Theodore Hughes-Riley, David M.L. Lilburn, Alan C. Dorkes, Karl F. Stupic, Dominick E. Shaw, Peter G. Morris, Ian P. Hall, Galina E. Pavlovskaya, Thomas Meersmann

Research output: Journal Publication › Article › peer-review

16 Citations (Scopus)

Abstract

Hyperpolarized ⁸³Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the ⁸³Kr hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched ⁸³Kr, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized ⁸³Kr MRI after krypton inhalation. Different ⁸³Kr relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T₁ weighted hyperpolarized ⁸³Kr MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast.

Original language	English
Pages (from-to)	48-53
Number of pages	6
Journal	Magnetic Resonance Imaging
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.mri.2013.08.007
Publication status	Published - Jan 2014
Externally published	Yes

Keywords

Kr
Cryogenic separation
Hyperpolarized
Kr-83 hyperpolarization
Krypton-83
Lung surfactant
Noble gas MRI
Nuclear electric quadrupole moment
Pre-clinical MRI
Pulmonary MRI
Quadrupolar relaxation
Spin polarization
Spin-exchange optical pumping
Surface sensitive contrast

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

Access to Document

10.1016/j.mri.2013.08.007

Cite this

@article{b600373b6a5147d08eece6da4003cdcb,

title = "Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr",

abstract = "Hyperpolarized 83Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the 83Kr hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched 83Kr, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized 83Kr MRI after krypton inhalation. Different 83Kr relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T1 weighted hyperpolarized 83Kr MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast.",

keywords = "Kr, Cryogenic separation, Hyperpolarized, Kr-83 hyperpolarization, Krypton-83, Lung surfactant, Noble gas MRI, Nuclear electric quadrupole moment, Pre-clinical MRI, Pulmonary MRI, Quadrupolar relaxation, Spin polarization, Spin-exchange optical pumping, Surface sensitive contrast",

author = "Six, {Joseph S.} and Theodore Hughes-Riley and Lilburn, {David M.L.} and Dorkes, {Alan C.} and Stupic, {Karl F.} and Shaw, {Dominick E.} and Morris, {Peter G.} and Hall, {Ian P.} and Pavlovskaya, {Galina E.} and Thomas Meersmann",

year = "2014",

month = jan,

doi = "10.1016/j.mri.2013.08.007",

language = "English",

volume = "32",

pages = "48--53",

journal = "Magnetic Resonance Imaging",

issn = "0730-725X",

publisher = "Elsevier Inc.",

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AU - Six, Joseph S.

AU - Hughes-Riley, Theodore

AU - Lilburn, David M.L.

AU - Dorkes, Alan C.

AU - Stupic, Karl F.

AU - Shaw, Dominick E.

AU - Morris, Peter G.

AU - Hall, Ian P.

AU - Pavlovskaya, Galina E.

AU - Meersmann, Thomas

PY - 2014/1

Y1 - 2014/1

N2 - Hyperpolarized 83Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the 83Kr hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched 83Kr, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized 83Kr MRI after krypton inhalation. Different 83Kr relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T1 weighted hyperpolarized 83Kr MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast.

AB - Hyperpolarized 83Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the 83Kr hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched 83Kr, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized 83Kr MRI after krypton inhalation. Different 83Kr relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T1 weighted hyperpolarized 83Kr MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast.

KW - Kr

KW - Cryogenic separation

KW - Hyperpolarized

KW - Kr-83 hyperpolarization

KW - Krypton-83

KW - Lung surfactant

KW - Noble gas MRI

KW - Nuclear electric quadrupole moment

KW - Pre-clinical MRI

KW - Pulmonary MRI

KW - Quadrupolar relaxation

KW - Spin polarization

KW - Spin-exchange optical pumping

KW - Surface sensitive contrast

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DO - 10.1016/j.mri.2013.08.007

M3 - Article

C2 - 24144493

AN - SCOPUS:84888134878

SN - 0730-725X

VL - 32

SP - 48

EP - 53

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

IS - 1

ER -