Abstract
The non-obese diabetic (NOD) mouse is a widely used animal model for study of autoimmune diseases, in particular human type 1 diabetes mellitus (T1DM). Identification of the subset of peptides that bind MHC molecules comprising the H-2g7 haplotype of NOD mouse and thereby representing potential NOD T-cell epitopes is important for research into the pathogenesis and immunotherapy of T1DM. The H-2g7 haplotype comprises the MHC class-I molecules Kd and Db and a single class-II molecule I-Ag7. We have developed a prediction system, PREDNOD, for accurate identification of peptides that bind the MHC molecules constituting the H-2g7 haplotype. PREDNOD is accessible at http://antigen.i2r.a-star.edu.sg/Ag7.
Original language | English |
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Pages (from-to) | 645-650 |
Number of pages | 6 |
Journal | Autoimmunity |
Volume | 39 |
Issue number | 8 |
DOIs | |
Publication status | Published - Dec 2006 |
Externally published | Yes |
Keywords
- Autoimmune diabetes
- I-A haplotype
- NOD
- Type 1 diabetes
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology