Potential Gains in Health-Adjusted Life Expectancy by Reducing Burden of Noncommunicable Diseases in 188 Countries: A Population-Based Study

Objectives: This article quantifies the potential gains in health-adjusted life expectancy for people aged 30 to 70 years (HALE_[30-70]) by examining the reductions in disability in addition to premature mortality from noncommunicable diseases (NCDs). Methods: We extracted data from the Global Burden of Disease Study 2019 for 4 major NCDs (cancers, cardiovascular diseases, chronic respiratory diseases, and diabetes mellitus) in 188 countries from 2010 to 2019. Estimates of the potential gains in HALE_[30-70] were based on a counterfactual analysis involving 3 alternative future scenarios: (1) achieve Sustainable Development Goals target 3.4 but do not make any progress on disability reduction, (2) achieve Sustainable Development Goals target 3.4 and eliminate NCD-related disability, and (3) eliminate all NCD-related mortality and disability. Results: In all scenarios, the high-income group has the greatest potential gains in HALE_[30-70], above the global average. For all specific causes, potential gains in HALE_[30-70] decrease as income levels fall. Across these 3 scenarios, the potential gains in HALE_[30-70] globally of reducing premature mortality for 4 major NCDs are 3.13 years, 4.53 years, and 7.32 years, respectively. In scenario A, all income groups have the greatest potential gains in HALE_[30-70] from diabetes and chronic respiratory diseases. In scenarios B and C, the high-income group has the greatest potential gains in HALE_[30-70] from cancer intervention, and the other income groups have the greatest potential gains in HALE_[30-70] from cardiovascular diseases intervention. Conclusion: Reducing premature death and disability from 4 major NCDs at once and attaching equal importance to each lead to a sizable improvement in HALE_[30-70].