Noxious stimulation accelerated the expression of c-fos protooncogene in cholecystokininergic and dopaminergic neurons in the ventral tegmental area

Qing Ping Ma; Yan Zhou; Ji Sheng Han

doi:10.1016/0196-9781(93)90145-7

Noxious stimulation accelerated the expression of c-fos protooncogene in cholecystokininergic and dopaminergic neurons in the ventral tegmental area

Qing Ping Ma, Yan Zhou, Ji Sheng Han

Research output: Journal Publication › Article › peer-review

18 Citations (Scopus)

Abstract

Cholecystokininergic (CCK) and dopaminergic systems in the midbrain have been implicated in pain modulation. In the present study, Fos immunoreactivity was used as a marker of neuronal activity to investigate if subcutaneous injection of formalin (a model of noxious stimulation) could activate the CCKergic and dopaminergic neurons in the midbrain. Noxious stimulation increased significantly the numbers of Fos-positive CCKergic and dopaminergic neurons in the ventral tegmental area (VTA), whereas no significant changes in the numbers of Fos-positive CCKerigc or dopaminergic neurons were observed in other midbrain nuclei. These results indicate that the VTA may play a role in pain modulation.

Original language	English
Pages (from-to)	561-566
Number of pages	6
Journal	Peptides
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/0196-9781(93)90145-7
Publication status	Published - 1993
Externally published	Yes

Keywords

Cholecystokinin
Dopamine
Noxious stimulation
Ventral tegmental area
c-fos protooncogene

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(93)90145-7

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title = "Noxious stimulation accelerated the expression of c-fos protooncogene in cholecystokininergic and dopaminergic neurons in the ventral tegmental area",

abstract = "Cholecystokininergic (CCK) and dopaminergic systems in the midbrain have been implicated in pain modulation. In the present study, Fos immunoreactivity was used as a marker of neuronal activity to investigate if subcutaneous injection of formalin (a model of noxious stimulation) could activate the CCKergic and dopaminergic neurons in the midbrain. Noxious stimulation increased significantly the numbers of Fos-positive CCKergic and dopaminergic neurons in the ventral tegmental area (VTA), whereas no significant changes in the numbers of Fos-positive CCKerigc or dopaminergic neurons were observed in other midbrain nuclei. These results indicate that the VTA may play a role in pain modulation.",

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year = "1993",

doi = "10.1016/0196-9781(93)90145-7",

language = "English",

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pages = "561--566",

journal = "Peptides",

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T1 - Noxious stimulation accelerated the expression of c-fos protooncogene in cholecystokininergic and dopaminergic neurons in the ventral tegmental area

AU - Ma, Qing Ping

AU - Zhou, Yan

AU - Han, Ji Sheng

PY - 1993

Y1 - 1993

N2 - Cholecystokininergic (CCK) and dopaminergic systems in the midbrain have been implicated in pain modulation. In the present study, Fos immunoreactivity was used as a marker of neuronal activity to investigate if subcutaneous injection of formalin (a model of noxious stimulation) could activate the CCKergic and dopaminergic neurons in the midbrain. Noxious stimulation increased significantly the numbers of Fos-positive CCKergic and dopaminergic neurons in the ventral tegmental area (VTA), whereas no significant changes in the numbers of Fos-positive CCKerigc or dopaminergic neurons were observed in other midbrain nuclei. These results indicate that the VTA may play a role in pain modulation.

AB - Cholecystokininergic (CCK) and dopaminergic systems in the midbrain have been implicated in pain modulation. In the present study, Fos immunoreactivity was used as a marker of neuronal activity to investigate if subcutaneous injection of formalin (a model of noxious stimulation) could activate the CCKergic and dopaminergic neurons in the midbrain. Noxious stimulation increased significantly the numbers of Fos-positive CCKergic and dopaminergic neurons in the ventral tegmental area (VTA), whereas no significant changes in the numbers of Fos-positive CCKerigc or dopaminergic neurons were observed in other midbrain nuclei. These results indicate that the VTA may play a role in pain modulation.

KW - Cholecystokinin

KW - Dopamine

KW - Noxious stimulation

KW - Ventral tegmental area

KW - c-fos protooncogene

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U2 - 10.1016/0196-9781(93)90145-7

DO - 10.1016/0196-9781(93)90145-7

M3 - Article

C2 - 8332552

AN - SCOPUS:0027195093

SN - 0196-9781

VL - 14

SP - 561

EP - 566

JO - Peptides

JF - Peptides

IS - 3

ER -

Noxious stimulation accelerated the expression of c-fos protooncogene in cholecystokininergic and dopaminergic neurons in the ventral tegmental area

Abstract

Keywords

ASJC Scopus subject areas

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