Hyperpolarized krypton-83 as a contrast agent for magnetic resonance imaging

Galina E. Pavlovskaya; Zackary I. Cleveland; Karl F. Stupic; Randall J. Basaraba; Thomas Meersmann

doi:10.1073/pnas.0509419102

Hyperpolarized krypton-83 as a contrast agent for magnetic resonance imaging

Galina E. Pavlovskaya, Zackary I. Cleveland, Karl F. Stupic, Randall J. Basaraba, Thomas Meersmann

Research output: Journal Publication › Article › peer-review

64 Citations (Scopus)

Abstract

For the first time, magnetic resonance imaging (MRI) with hyperpolarized (hp) krypton-83 (⁸³Kr) has become available. The relaxation of the nuclear spin of ⁸³Kr atoms (I = 9/2) is driven by quadrupolar interactions during brief adsorption periods on surrounding material interfaces. Experiments in model systems reveal that the longitudinal relaxation of hp ⁸³Kr gas strongly depends on the chemical composition of the materials. The relaxation-weighted contrast in hp ⁸³Kr MRI allows for the distinction between hydrophobic and hydrophilic surfaces. The feasibility of hp ⁸³Kr MRI of airways is tested in canine lung tissue by using krypton gas with natural abundance isotopic distribution. Additionally, the influence of magnetic field strength and the presence of a breathable concentration of molecular oxygen on longitudinal relaxation are investigated.

Original language	English
Pages (from-to)	18275-18279
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	102
Issue number	51
DOIs	https://doi.org/10.1073/pnas.0509419102
Publication status	Published - 20 Dec 2005
Externally published	Yes

Keywords

MRI
NMR
Optical pumping
Pulmonary
Xenon

ASJC Scopus subject areas

General

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10.1073/pnas.0509419102

Cite this

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title = "Hyperpolarized krypton-83 as a contrast agent for magnetic resonance imaging",

abstract = "For the first time, magnetic resonance imaging (MRI) with hyperpolarized (hp) krypton-83 (83Kr) has become available. The relaxation of the nuclear spin of 83Kr atoms (I = 9/2) is driven by quadrupolar interactions during brief adsorption periods on surrounding material interfaces. Experiments in model systems reveal that the longitudinal relaxation of hp 83Kr gas strongly depends on the chemical composition of the materials. The relaxation-weighted contrast in hp 83Kr MRI allows for the distinction between hydrophobic and hydrophilic surfaces. The feasibility of hp 83Kr MRI of airways is tested in canine lung tissue by using krypton gas with natural abundance isotopic distribution. Additionally, the influence of magnetic field strength and the presence of a breathable concentration of molecular oxygen on longitudinal relaxation are investigated.",

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AU - Pavlovskaya, Galina E.

AU - Cleveland, Zackary I.

AU - Stupic, Karl F.

AU - Basaraba, Randall J.

AU - Meersmann, Thomas

PY - 2005/12/20

Y1 - 2005/12/20

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AB - For the first time, magnetic resonance imaging (MRI) with hyperpolarized (hp) krypton-83 (83Kr) has become available. The relaxation of the nuclear spin of 83Kr atoms (I = 9/2) is driven by quadrupolar interactions during brief adsorption periods on surrounding material interfaces. Experiments in model systems reveal that the longitudinal relaxation of hp 83Kr gas strongly depends on the chemical composition of the materials. The relaxation-weighted contrast in hp 83Kr MRI allows for the distinction between hydrophobic and hydrophilic surfaces. The feasibility of hp 83Kr MRI of airways is tested in canine lung tissue by using krypton gas with natural abundance isotopic distribution. Additionally, the influence of magnetic field strength and the presence of a breathable concentration of molecular oxygen on longitudinal relaxation are investigated.

KW - MRI

KW - NMR

KW - Optical pumping

KW - Pulmonary

KW - Xenon

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Hyperpolarized krypton-83 as a contrast agent for magnetic resonance imaging

Abstract

Keywords

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