TY - JOUR
T1 - Functional cellulose-based beads for drug delivery
T2 - Preparation, functionalization, and applications
AU - El Allaoui, Brahim
AU - Benzeid, Hanane
AU - Zari, Nadia
AU - Qaiss, Abou el kacem
AU - Bouhfid, Rachid
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/10
Y1 - 2023/10
N2 - In pharmaceutical technology, maintaining and controlling the rate of drug release is essential to ensure optimal therapeutic effects, consistent dosage, sustained release, and compliance with treatment by the patient. Cellulose-based beads have distinctive features that include biodegradability, biocompatibility, safety, cost performance, and stability under varying conditions, particularly humidity, pH, and temperature changes. Additionally, due to their versatility, they can be easily functionalized using a range of chemical groups to control the release of drugs and better target particular tissues. Moreover, the porous structure of cellulose-based beads ensures sustained drug release for an extended period. This review deals with producing functional beads from cellulose and its derivatives, which offer the potential to be used as a drug delivery system. In the first part of the review, we present the present knowledge on the extraction methods and properties of cellulose, its different morphological forms, and its applications in drug delivery. In the second part, we discuss the methods of production of cellulose beads production methods, including dissolution/regeneration and simple mechanical process along with their functionalization routes. The last part of the paper focuses on the use of cellulose-based beads as carriers for drug delivery applications, with a focus on the approaches used to load the beads with drugs, and the mechanism of drug release as well as the controlled release.
AB - In pharmaceutical technology, maintaining and controlling the rate of drug release is essential to ensure optimal therapeutic effects, consistent dosage, sustained release, and compliance with treatment by the patient. Cellulose-based beads have distinctive features that include biodegradability, biocompatibility, safety, cost performance, and stability under varying conditions, particularly humidity, pH, and temperature changes. Additionally, due to their versatility, they can be easily functionalized using a range of chemical groups to control the release of drugs and better target particular tissues. Moreover, the porous structure of cellulose-based beads ensures sustained drug release for an extended period. This review deals with producing functional beads from cellulose and its derivatives, which offer the potential to be used as a drug delivery system. In the first part of the review, we present the present knowledge on the extraction methods and properties of cellulose, its different morphological forms, and its applications in drug delivery. In the second part, we discuss the methods of production of cellulose beads production methods, including dissolution/regeneration and simple mechanical process along with their functionalization routes. The last part of the paper focuses on the use of cellulose-based beads as carriers for drug delivery applications, with a focus on the approaches used to load the beads with drugs, and the mechanism of drug release as well as the controlled release.
KW - Beads preparation
KW - Cellulose functionalization
KW - Cellulose-based beads
KW - Controlled release
KW - Drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85170102676&partnerID=8YFLogxK
U2 - 10.1016/j.jddst.2023.104899
DO - 10.1016/j.jddst.2023.104899
M3 - Review article
AN - SCOPUS:85170102676
SN - 1773-2247
VL - 88
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
M1 - 104899
ER -